Grid-cell modules remain coordinated when neural activity is dissociated from external sensory cues

Torgeir Waaga, Haggai Agmon*, Valentin A. Normand, Anne Nagelhus, Richard J. Gardner, May Britt Moser, Edvard I. Moser*, Yoram Burak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The representation of an animal's position in the medial entorhinal cortex (MEC) is distributed across several modules of grid cells, each characterized by a distinct spatial scale. The population activity within each module is tightly coordinated and preserved across environments and behavioral states. Little is known, however, about the coordination of activity patterns across modules. We analyzed the joint activity patterns of hundreds of grid cells simultaneously recorded in animals that were foraging either in the light, when sensory cues could stabilize the representation, or in darkness, when such stabilization was disrupted. We found that the states of different modules are tightly coordinated, even in darkness, when the internal representation of position within the MEC deviates substantially from the true position of the animal. These findings suggest that internal brain mechanisms dynamically coordinate the representation of position in different modules, ensuring that they jointly encode a coherent and smooth trajectory.

Original languageAmerican English
Pages (from-to)1843-1856.e6
JournalNeuron
Volume110
Issue number11
DOIs
StatePublished - 1 Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

Keywords

  • entorhinal cortex
  • grid cells
  • neural circuits
  • neural coding
  • neural decoding
  • population coding
  • spatial coding
  • spatial memory

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