TY - JOUR
T1 - GTP-receptor interrelationships in adenylate cyclase systems theoretical considerations
AU - Levitzki, Alexander
PY - 1980
Y1 - 1980
N2 - Theoretical considerations concerning the effect of guanyl nucleotides on hormone-dependent adenylate cyclases show that the phenomena observed can be accounted for by postulating only one type of guanyl nucleotide regulatory site. The binding of GTP or of its non-hydrolizable analogues to the guanyl nucleotide regulatory site induces cyclase activation and may induce a decrease in agonist affinity towards the receptor. From basic principles it is shown that the potency ratio of guanyl nucleotides in inducing the decreased agonist affinity does not necessarily reflect their order of affinities to the GTP regulatory site.
AB - Theoretical considerations concerning the effect of guanyl nucleotides on hormone-dependent adenylate cyclases show that the phenomena observed can be accounted for by postulating only one type of guanyl nucleotide regulatory site. The binding of GTP or of its non-hydrolizable analogues to the guanyl nucleotide regulatory site induces cyclase activation and may induce a decrease in agonist affinity towards the receptor. From basic principles it is shown that the potency ratio of guanyl nucleotides in inducing the decreased agonist affinity does not necessarily reflect their order of affinities to the GTP regulatory site.
KW - Adenylate cyclase
KW - GTP-receptor binding
UR - https://www.scopus.com/pages/publications/0018884571
U2 - 10.1016/0304-4165(80)90391-8
DO - 10.1016/0304-4165(80)90391-8
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C2 - 7370300
AN - SCOPUS:0018884571
SN - 0304-4165
VL - 628
SP - 419
EP - 424
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
IS - C
ER -