Guanylyl 2′-5′ guanosine as an inhibitor of ribonuclease T1

Moshe D. White; Sara Rapoport; Yehuda Lapidot

doi:10.1016/S0006-291X(77)80089-2

Guanylyl 2′-5′ guanosine as an inhibitor of ribonuclease T₁

Moshe D. White^*, Sara Rapoport, Yehuda Lapidot

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Guanylyl 2′-5′ nucleosides were tested for their ability to inhibit the depolymerization activity of ribonuclease T₁. It was found that the guanylyl 2′-5′ purines had a significant inhibitory effect. Guanylyl 2′-5′ guanosine was the strongest inhibitor. However, guanylyl 2′-5′ pyrimidine nucleosides did not inhibit at all.

Original language	English
Pages (from-to)	1084-1087
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	77
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(77)80089-2
State	Published - 8 Aug 1977

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abstract = "Guanylyl 2′-5′ nucleosides were tested for their ability to inhibit the depolymerization activity of ribonuclease T1. It was found that the guanylyl 2′-5′ purines had a significant inhibitory effect. Guanylyl 2′-5′ guanosine was the strongest inhibitor. However, guanylyl 2′-5′ pyrimidine nucleosides did not inhibit at all.",

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AU - White, Moshe D.

AU - Rapoport, Sara

AU - Lapidot, Yehuda

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AB - Guanylyl 2′-5′ nucleosides were tested for their ability to inhibit the depolymerization activity of ribonuclease T1. It was found that the guanylyl 2′-5′ purines had a significant inhibitory effect. Guanylyl 2′-5′ guanosine was the strongest inhibitor. However, guanylyl 2′-5′ pyrimidine nucleosides did not inhibit at all.

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Guanylyl 2′-5′ guanosine as an inhibitor of ribonuclease T₁

Abstract

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