Hallmarks of pluripotency

Alejandro De Los Angeles, Francesco Ferrari, Ruibin Xi, Yuko Fujiwara, Nissim Benvenisty, Hongkui Deng, Konrad Hochedlinger, Rudolf Jaenisch, Soohyun Lee, Harry G. Leitch, M. William Lensch, Ernesto Lujan, Duanqing Pei, Janet Rossant, Marius Wernig, Peter J. Park, George Q. Daley*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

295 Scopus citations

Abstract

Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.

Original languageAmerican English
Pages (from-to)469-478
Number of pages10
JournalNature
Volume525
Issue number7570
DOIs
StatePublished - 23 Sep 2015

Bibliographical note

Publisher Copyright:
© 2015 Macmillan Publishers Limited.

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