Hallmarks of pluripotency

Alejandro De Los Angeles; Francesco Ferrari; Ruibin Xi; Yuko Fujiwara; Nissim Benvenisty; Hongkui Deng; Konrad Hochedlinger; Rudolf Jaenisch; Soohyun Lee; Harry G. Leitch; M. William Lensch; Ernesto Lujan; Duanqing Pei; Janet Rossant; Marius Wernig; Peter J. Park; George Q. Daley

doi:10.1038/nature15515

Hallmarks of pluripotency

Alejandro De Los Angeles, Francesco Ferrari, Ruibin Xi, Yuko Fujiwara, Nissim Benvenisty, Hongkui Deng, Konrad Hochedlinger, Rudolf Jaenisch, Soohyun Lee, Harry G. Leitch, M. William Lensch, Ernesto Lujan, Duanqing Pei, Janet Rossant, Marius Wernig, Peter J. Park, George Q. Daley^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Review article › peer-review

299 Scopus citations

Abstract

Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.

Original language	English
Pages (from-to)	469-478
Number of pages	10
Journal	Nature
Volume	525
Issue number	7570
DOIs	https://doi.org/10.1038/nature15515
State	Published - 23 Sep 2015

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© 2015 Macmillan Publishers Limited.

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AU - De Los Angeles, Alejandro

AU - Ferrari, Francesco

AU - Xi, Ruibin

AU - Fujiwara, Yuko

AU - Benvenisty, Nissim

AU - Deng, Hongkui

AU - Hochedlinger, Konrad

AU - Jaenisch, Rudolf

AU - Lee, Soohyun

AU - Leitch, Harry G.

AU - Lensch, M. William

AU - Lujan, Ernesto

AU - Pei, Duanqing

AU - Rossant, Janet

AU - Wernig, Marius

AU - Park, Peter J.

AU - Daley, George Q.

PY - 2015/9/23

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Hallmarks of pluripotency

Abstract

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