Halogenated analogs of tri-O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies.

Jallal M. Gnaim; Philip M. Keehn; Bernard S. Green

doi:10.1016/S0040-4039(00)78886-1

Halogenated analogs of tri-O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies.

Jallal M. Gnaim^*, Philip M. Keehn, Bernard S. Green

^*Corresponding author for this work

Faculty of Medicine

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Abstract

Halogenated trisalicylide derivatives 1-6, representing three-fold symmetric C₃ "home trimmers" as well as dissymmetric C₁ "mixed trimers" have been synthesized. Clathration studies indicate that these halogenated TOT analogs do not form clathrates. Reductive removal of the halogen was demonstrated for analog 2, providing a new entry to TOT-based host molecules.

Original language	English
Pages (from-to)	2883-2886
Number of pages	4
Journal	Tetrahedron Letters
Volume	33
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4039(00)78886-1
State	Published - 12 May 1992

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abstract = "Halogenated trisalicylide derivatives 1-6, representing three-fold symmetric C3 {"}home trimmers{"} as well as dissymmetric C1 {"}mixed trimers{"} have been synthesized. Clathration studies indicate that these halogenated TOT analogs do not form clathrates. Reductive removal of the halogen was demonstrated for analog 2, providing a new entry to TOT-based host molecules.",

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AU - Keehn, Philip M.

AU - Green, Bernard S.

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Y1 - 1992/5/12

N2 - Halogenated trisalicylide derivatives 1-6, representing three-fold symmetric C3 "home trimmers" as well as dissymmetric C1 "mixed trimers" have been synthesized. Clathration studies indicate that these halogenated TOT analogs do not form clathrates. Reductive removal of the halogen was demonstrated for analog 2, providing a new entry to TOT-based host molecules.

AB - Halogenated trisalicylide derivatives 1-6, representing three-fold symmetric C3 "home trimmers" as well as dissymmetric C1 "mixed trimers" have been synthesized. Clathration studies indicate that these halogenated TOT analogs do not form clathrates. Reductive removal of the halogen was demonstrated for analog 2, providing a new entry to TOT-based host molecules.

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Halogenated analogs of tri-O-thymotide (TOT) and tri-3-(2-butyl)-6-methylsalicylide (TSBS): synthesis and clathration studies.

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