Haloperidol-induced plasma prolactin release: Sensitivity, reliability, and comparison to haloperidol antagonism of dopamine agonist-induced stereotyped behavior in the rat

J. J. Feigenbaum; B. H. Moon; R. Catterton; J. Yanai; H. L. Klawans

doi:10.1007/BF00433748

Haloperidol-induced plasma prolactin release: Sensitivity, reliability, and comparison to haloperidol antagonism of dopamine agonist-induced stereotyped behavior in the rat

J. J. Feigenbaum^*
, B. H. Moon
, R. Catterton
, J. Yanai
, H. L. Klawans

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effects of a known antipsychotic agent (haloperidol) were assessed using both a behavioral model and a prolactin (PRL) model for screening potential antipsychotic drugs in the rat. The PRL model was found to be highly reliable and more sensitive than the behavioral model.

Original language	English
Pages (from-to)	383-384
Number of pages	2
Journal	Psychopharmacology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1007/BF00433748
State	Published - Dec 1982

Keywords

Apomorphine
Haloperidol
Plasma prolactin
Screening model
Stereotypy

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10.1007/BF00433748

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abstract = "The effects of a known antipsychotic agent (haloperidol) were assessed using both a behavioral model and a prolactin (PRL) model for screening potential antipsychotic drugs in the rat. The PRL model was found to be highly reliable and more sensitive than the behavioral model.",

keywords = "Apomorphine, Haloperidol, Plasma prolactin, Screening model, Stereotypy",

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AU - Yanai, J.

AU - Klawans, H. L.

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KW - Apomorphine

KW - Haloperidol

KW - Plasma prolactin

KW - Screening model

KW - Stereotypy

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Haloperidol-induced plasma prolactin release: Sensitivity, reliability, and comparison to haloperidol antagonism of dopamine agonist-induced stereotyped behavior in the rat

Abstract

Keywords

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