TY - JOUR
T1 - Heat acclimation alters nitric oxide response in the splanchnic circulation
AU - Haddad, W.
AU - Horowitz, M.
PY - 1999/10
Y1 - 1999/10
N2 - The role of nitric oxide (NO) mediated vasorelaxation in splanchnic blood flow during heat stress was studied in rats before and after heat acclimation (1 month, at 34°C). Superior mesenteric artery and portal vein blood flows were measured on-line in the conscious rats during heat stress at 40°C and 42°C before and after LNNA administration. NO mediated vasorelaxation in these vessels was studies in vitro, in response to pilocarpine, Ca ionophore and Na nitroprusside stimulation. The data suggest that NO is an integral part of the thermoregulatory splanchnic vasomotor response, and that heat acclimation enhances its regulatory importance.
AB - The role of nitric oxide (NO) mediated vasorelaxation in splanchnic blood flow during heat stress was studied in rats before and after heat acclimation (1 month, at 34°C). Superior mesenteric artery and portal vein blood flows were measured on-line in the conscious rats during heat stress at 40°C and 42°C before and after LNNA administration. NO mediated vasorelaxation in these vessels was studies in vitro, in response to pilocarpine, Ca ionophore and Na nitroprusside stimulation. The data suggest that NO is an integral part of the thermoregulatory splanchnic vasomotor response, and that heat acclimation enhances its regulatory importance.
UR - http://www.scopus.com/inward/record.url?scp=0033380593&partnerID=8YFLogxK
U2 - 10.1016/S0306-4565(99)00054-6
DO - 10.1016/S0306-4565(99)00054-6
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AN - SCOPUS:0033380593
SN - 0306-4565
VL - 24
SP - 403
EP - 408
JO - Journal of Thermal Biology
JF - Journal of Thermal Biology
IS - 5-6
ER -