Hedgehogs and Squirrels as Hosts of Zoonotic Bartonella Species

Karolina Majerová*, Ricardo Gutiérrez, Manoj Fonville, Václav Hönig, Petr Papežík, Lada Hofmannová, Paulina Maria Lesiczka, Yaarit Nachum-Biala, Daniel Růžek, Hein Sprong, Shimon Harrus, David Modrý, Jan Votýpka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Free-living animals frequently play a key role in the circulation of various zoonotic vector-borne pathogens. Bacteria of the genus Bartonella are transmitted by blood-feeding arthropods and infect a large range of mammals. Although only several species have been identified as causative agents of human disease, it has been proposed that any Bartonella species found in animals may be capable of infecting humans. Within a wide-ranging survey in various geographical regions of the Czech Republic, cadavers of accidentally killed synurbic mammalian species, namely Eurasian red squirrel (Sciurus vulgaris), European hedgehog (Erinaceus europaeus) and Northern white-breasted hedgehog (Erinaceus roumanicus), were sampled and tested for Bartonella presence using multiple PCR reaction approach targeting several DNA loci. We demonstrate that cadavers constitute an available and highly useful source of biological material for pathogen screening. High infection rates of Bartonella spp., ranging from 24% to 76%, were confirmed for all three tested mammalian species, and spleen, ear, lung and liver tissues were demonstrated as the most suitable for Bartonella DNA detection. The wide spectrum of Bartonella spp. that were identified includes three species with previously validated zoonotic potential, B. grahamii, B. melophagi and B. washoensis, accompanied by ‘Candidatus B. rudakovii’ and two putative novel species, Bartonella sp. ERIN and Bartonella sp. SCIER.

Original languageAmerican English
Article number686
JournalPathogens
Volume10
Issue number6
DOIs
StatePublished - Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • B. melophagi
  • B. rochalimae
  • B. washoensis
  • Bartonella grahamii
  • hedgehogs
  • multiple PCR
  • squirrels
  • vector-borne diseases
  • zoonoses
  • ‘Candidatus B. rudakovii’

Fingerprint

Dive into the research topics of 'Hedgehogs and Squirrels as Hosts of Zoonotic Bartonella Species'. Together they form a unique fingerprint.

Cite this