Hemodynamic response magnetic resonance imaging: Application for renal hemodynamic characterization

Zohar Milman, Samuel N. Heyman, Nathalie Corchia, Yifat Edrei, Jonathan H. Axelrod, Chrisitian Rosenberger, Galia Tsarfati, Rinat Abramovitch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background The clinical use of iodinated radiocontrast agents or gadolinium for renal perfusion imaging is limited in the presence of renal dysfunction. We have previously demonstrated the feasibility of hemodynamic response imaging (HRI), a functional magnetic resonance imaging (MRI) method combined with hypercapnia and hypercapnic-hyperoxia, for monitoring changes in liver perfusion and hemodynamics. The aim of the present study was to evaluate the utility of HRI for monitoring changes in renal perfusion and hemodynamics. Methods Renal HRI maps were acquired during graded hypercapnia (95% air + 5% CO2) and hypercapnic-hyperoxia (95% O2 + 5% CO2) in control mice. The utility of HRI for monitoring changes in renal perfusion and oxygenation was evaluated using pharmacological inhibition of nitric oxide synthase and cycloxygenase as well as in rhabdomyolysis-induced acute kidney injury (AKI) in mice. HRI results were further interpreted using Doppler ultrasound (US).ResultsRenal HRI maps revealed pronounced signal-intensity changes in response to both hypercapnia and hypercapnic-hyperoxia, reflecting intense vascular reactivity. These changes were significantly attenuated following the pharmacological intervention and during AKI, corresponding with hampered perfusion dynamics, as confirmed by Doppler US. Conclusions The applicability of the non-invasive HRI method suggests its potential use for the evaluation of renal perfusion and vascular reactivity, excluding the need for contrast-agent administration.

Original languageAmerican English
Pages (from-to)1150-1156
Number of pages7
JournalNephrology Dialysis Transplantation
Issue number5
StatePublished - May 2013
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by a grant from the Israel Science Foundation to R.A. (1243/10) and to J.H.A. (891/08).


  • MRI
  • acute kidney injury
  • hypoxia
  • kidney imaging
  • renal blood flow


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