Hemoglobin nonrecovery following acute myocardial infarction is a biomarker of poor outcome: A retrospective database study

Eran Leshem-Rubinow*, Arie Steinvil, Ori Rogowski, David Zeltser, Shlomo Berliner, Dahlia Weitzman, Raanan Raz, Gabriel Chodick, Varda Shalev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background Anemia on admission and during hospitalization is associated with poor short and long term prognosis among patients with acute coronary syndrome (ACS). Our objective was to examine the prognostic implications of longitudinal hemoglobin (Hb) levels following a first acute myocardial infarction (AMI). Methods We utilized data obtained from the computerized database of a large community based health care maintenance organization to identify patients who survived for at least 6 months following a first AMI, during the years 2003-2010. Hazard ratios were calculated using Cox proportional regression models with various Hb measurements as dependent variables, and net reclassification improvement (NRI) was applied to evaluate the prognostic usefulness of these Hb measurements. Results Last Hb measurement during a 6-24 month follow-up period was found to have the highest prognostic power. In males, Hb levels below 13 g/dL were gradually associated with a higher risk of events, reaching a HR of 4.13 at Hb levels < 11 g/dL. In females, only Hb levels lower than 11 g/dL were significantly associated with a higher event rate (HR = 2.42, p = 0.003). Hb decrease was significantly associated with an increased risk in both genders, even among non-anemic patients at baseline. Conclusions Anemia and Hb decrement following a first AMI are associated with worse prognosis and elevated risk of combined all cause mortality and recurrent cardiac events.

Original languageAmerican English
Pages (from-to)349-353
Number of pages5
JournalInternational Journal of Cardiology
Issue number5
StatePublished - 20 Nov 2013
Externally publishedYes


  • Acute myocardial infarction
  • Anemia
  • Hemoglobin


Dive into the research topics of 'Hemoglobin nonrecovery following acute myocardial infarction is a biomarker of poor outcome: A retrospective database study'. Together they form a unique fingerprint.

Cite this