Abstract
Nanoparticles (NP) have drawn increasing interest from many fields in medicine and are a relatively new class of biomedical products. Because there are concerns about the health effects of nanoparticles, it is important to understand how nanoparticles interact specifically with red blood cells (RBC), a central object in the blood circulation. As numerous studies that have examined NP/RBC interaction concentrated on the hemolytic potential of nanoparticles, we describe an investigation of hemolytic activity of polystyrene nanoparticles (PS-NP) in protein free medium and its modulation by albumin. We found that treatment of RBCs with PS-NP induces hemolysis (dose and particle size dependent) in plasma free medium but not in full plasma or in buffer, which contain albumin. Critical albumin concentration is 0.05% wt. According to our results hemolytic effect of nanoparticles is strongly modulated by protein concentration in the medium.
| Original language | English |
|---|---|
| Article number | 6086628 |
| Pages (from-to) | 259-261 |
| Number of pages | 3 |
| Journal | IEEE Transactions on Nanobioscience |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2011 |
Keywords
- Erythrocyte
- hemolysis
- nanoparticles