Hemophagocytic lymphohistiocytosis associated with visceral leishmaniasis

Daphna Marom, Itamar Offer, Hanna Tamary, C. L. Jaffe, Ben Zion Garty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A 2-year-old child presented with fever and hepatosplenomegaly. Laboratory findings showed pancytopenia, hypertriglyceridemia, hyperferritinemia, and high levels of soluble-IL2 receptors. Initial bone marrow aspiration and biopsy revealed mild hemophagocytosis. A diagnosis of hemophagocytic lymphohistiocytosis was made and appropriate treatment was begun. Repeated marrow aspiration performed because of lack of clinical response revealed Leishmania amastigotes in macrophages in addition to active hemophagocytosis. Treatment with liposomal amphotericin resulted with rapid recovery. Visceral leishmaniasis should be considered in the differential diagnosis of hemophagocytic syndrome.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalPediatric Hematology and Oncology
Volume18
Issue number1
DOIs
StatePublished - 2001

Keywords

  • Hemophagocytosis
  • Visceral leishmaniasis

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