Hepatitis B virus revaccination with standard versus Pre-S vaccine in previously immunized patients with celiac disease

Merav Heshin-Bekenstein*, Dan Turner, Raanan Shamir, Maskit Bar-Meir, Ron Dagan, Noam Zevit, Ari Silbermintz

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations


    Objective: Previous studies have suggested that hepatitis B virus (HBV) vaccines may be less immunogenic in individuals with celiac disease (CD). A pre-S vaccine (Sci-B-Vac) has demonstrated superior immunogenicity comparedwith standardHBVvaccines in several diseases.Wecompared the shortterm immunogenicity of a pre-S vaccine with a HBV vaccine (Engerix B) for repeat vaccination of seronegative, previously immunized patients with CD. Methods: Participants were 1 to 18-year-old children with CD who despite standard HBV vaccines in infancy had nonprotective hepatitis B surface antibody (HBs-Ab) concentrations (≤10 mIU/mL). Patients were randomized to receive either Engerix B or pre-S vaccine. HBs-Ab concentrations were measured 1 month after the first dose. For those who had not responded after 1 dose, measurement was repeated after the third dose. Results: Children (n=82) were analyzed (42 pre-S vaccine and 40 Engerix B). Baseline characteristics were similar for both groups, including glutenfree diet status. Both arms showed high response rates following the first injection: 41 (98%) versus 35 (87%) for pre-S vaccine and Engerix B recipients, respectively (P=0.08). All other patients responded when measured after dose 3. HBs-Ab concentrations (mIU/mL) were higher in the pre-S vaccine group (median 925, interquartile range [IQR] 424-1000) than the Engerix B group (median 363, IQR 106-996, P=0.005). Twenty (48%) of the pre-S vaccine recipients were ''high responders'' (>1000 mIU/ mL) versus 10 (25%) in Engerix B recipients (P=0.008). Conclusions: Both vaccines elicited adequate booster responses in most previously vaccinated patients with CD with nonprotective HBs-Ab concentrations. Pre-S vaccine administration resulted in higher Hbs-Ab concentrations. Our data suggest that a single dose of either vaccine is sufficient to raise titers to protective levels in most patients with CD.

    Original languageAmerican English
    Pages (from-to)400-403
    Number of pages4
    JournalJournal of Pediatric Gastroenterology and Nutrition
    Issue number4
    StatePublished - 1 Oct 2015

    Bibliographical note

    Publisher Copyright:
    Copyright © 2015 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.


    • Celiac disease
    • Hepatitis B vaccine
    • Pre-S vaccine
    • Randomized control trial


    Dive into the research topics of 'Hepatitis B virus revaccination with standard versus Pre-S vaccine in previously immunized patients with celiac disease'. Together they form a unique fingerprint.

    Cite this