TY - JOUR
T1 - Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system
AU - Tzur, Yonatan B.
AU - Friedland, Ari E.
AU - Nadarajan, Saravanapriah
AU - Church, George M.
AU - Calarco, John A.
AU - Colaiácovo, Monica P.
PY - 2013
Y1 - 2013
N2 - We adapted the CRISPR-Cas9 system for template-mediated repair of targeted double-strand breaks via homologous recombination in Caenorhabditis elegans, enabling customized and efficient genome editing. This system can be used to create specific insertions, deletions, and base pair changes in the germline of C. elegans.
AB - We adapted the CRISPR-Cas9 system for template-mediated repair of targeted double-strand breaks via homologous recombination in Caenorhabditis elegans, enabling customized and efficient genome editing. This system can be used to create specific insertions, deletions, and base pair changes in the germline of C. elegans.
UR - http://www.scopus.com/inward/record.url?scp=84884968656&partnerID=8YFLogxK
U2 - 10.1534/genetics.113.156075
DO - 10.1534/genetics.113.156075
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C2 - 23979579
AN - SCOPUS:84884968656
SN - 0016-6731
VL - 195
SP - 1181
EP - 1185
JO - Genetics
JF - Genetics
IS - 3
ER -