Abstract
The coupling of substituted halobenzenes to form biphenyls is effected at moderate temperature (65°C) using a reducing agent such as a formate salt and a base (NaOH) in the presence of a catalytic amount of phase-transfer catalyst and 5% Pd/C catalyst. The reaction conditions can be optimized to give reasonable selectivity, and the competing reduction process is minimized. The roles of temperature, catalyst loading, reducing agents, the base, and the phase-transfer catalyst are discussed. The catalyst can be efficiently recycled. However, an entirely different course of reaction occurs when a mixture of halobenzenes is utilized.
Original language | English |
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Pages (from-to) | 297-300 |
Number of pages | 4 |
Journal | Organic Process Research and Development |
Volume | 6 |
Issue number | 3 |
DOIs | |
State | Published - 2002 |