TY - JOUR
T1 - Heterogeneous Rh/C-catalyzed direct reductive coupling of haloaryls to biaryls in water
AU - Mukhopadhyay, Sudip
AU - Joshi, Ashutosh V.
AU - Peleg, Liat
AU - Sasson, Yoel
PY - 2003/1
Y1 - 2003/1
N2 - Reductive coupling of haloaryls and substituted haloaryls to the respective biaryls is effected in water with good selectivity, using a reducing agent such as formate salts and a base, NaOH, in the presence of a catalytic amount of PEG-400 and 5% Rh/C catalyst at 115 °C temperature. The catalyst can be recycled. The competing reduction reaction is minimized with proper alteration of the operating conditions. The role of temperature, catalyst loading, reducing agents, base, and PEG-400 are discussed. The reaction follows a zero-order kinetics.
AB - Reductive coupling of haloaryls and substituted haloaryls to the respective biaryls is effected in water with good selectivity, using a reducing agent such as formate salts and a base, NaOH, in the presence of a catalytic amount of PEG-400 and 5% Rh/C catalyst at 115 °C temperature. The catalyst can be recycled. The competing reduction reaction is minimized with proper alteration of the operating conditions. The role of temperature, catalyst loading, reducing agents, base, and PEG-400 are discussed. The reaction follows a zero-order kinetics.
UR - http://www.scopus.com/inward/record.url?scp=0037280685&partnerID=8YFLogxK
U2 - 10.1021/op020080m
DO - 10.1021/op020080m
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AN - SCOPUS:0037280685
SN - 1083-6160
VL - 7
SP - 44
EP - 46
JO - Organic Process Research and Development
JF - Organic Process Research and Development
IS - 1
ER -