Heterotransplantation of experimentally induced sheep lung adenomatosis into nude mice.

A. Zimber*, K. Perk, I. Hod, S. Irving, Y. Yegana

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Male ICR nude mice inoculated subcutaneously with minced tissue obtained from pulmonary adenomatosis of sheep which was induced by RNA type-C retrovirus developed a transplant which contained cysts lined by a proliferative epithelium. These cysts showed several characteristics of the epithelial tumour cells of origin, such as high glycogen content and secretion of mucin. Microinvasion of epithelial cells from the adenomatous cysts into the stroma was observed. The stromal tissue demonstrated islets of cartilage. It was concluded that virus-induced pulmonary carcinoma of sheep can be transplanted and grown in nude mice.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalResearch in Veterinary Science
Volume36
Issue number1
DOIs
StatePublished - Jan 1984

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