Heterotransplantation of experimentally induced sheep lung adenomatosis into nude mice.

A. Zimber; K. Perk; I. Hod; S. Irving; Y. Yegana

doi:10.1016/s0034-5288(18)32012-5

Heterotransplantation of experimentally induced sheep lung adenomatosis into nude mice.

A. Zimber^*
, K. Perk
, I. Hod
, S. Irving
, Y. Yegana

^*Corresponding author for this work

Department of Animal Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Male ICR nude mice inoculated subcutaneously with minced tissue obtained from pulmonary adenomatosis of sheep which was induced by RNA type-C retrovirus developed a transplant which contained cysts lined by a proliferative epithelium. These cysts showed several characteristics of the epithelial tumour cells of origin, such as high glycogen content and secretion of mucin. Microinvasion of epithelial cells from the adenomatous cysts into the stroma was observed. The stromal tissue demonstrated islets of cartilage. It was concluded that virus-induced pulmonary carcinoma of sheep can be transplanted and grown in nude mice.

Original language	English
Pages (from-to)	122-124
Number of pages	3
Journal	Research in Veterinary Science
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/s0034-5288(18)32012-5
State	Published - Jan 1984

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10.1016/s0034-5288(18)32012-5

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title = "Heterotransplantation of experimentally induced sheep lung adenomatosis into nude mice.",

abstract = "Male ICR nude mice inoculated subcutaneously with minced tissue obtained from pulmonary adenomatosis of sheep which was induced by RNA type-C retrovirus developed a transplant which contained cysts lined by a proliferative epithelium. These cysts showed several characteristics of the epithelial tumour cells of origin, such as high glycogen content and secretion of mucin. Microinvasion of epithelial cells from the adenomatous cysts into the stroma was observed. The stromal tissue demonstrated islets of cartilage. It was concluded that virus-induced pulmonary carcinoma of sheep can be transplanted and grown in nude mice.",

author = "A. Zimber and K. Perk and I. Hod and S. Irving and Y. Yegana",

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AU - Irving, S.

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Heterotransplantation of experimentally induced sheep lung adenomatosis into nude mice.

Abstract

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