Abstract
Faigenbaum-Romm et al. analyze data of sRNA-target pairs and transcriptome measurements, revealing that only a subset of targets shows expression changes under overexpression of the sRNA. Analyzing various target features, they find that competition among targets over binding the chaperon Hfq plays a major role in the regulatory outcome.
Original language | English |
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Pages (from-to) | 3127-3138.e6 |
Journal | Cell Reports |
Volume | 30 |
Issue number | 9 |
DOIs | |
State | Published - 3 Mar 2020 |
Bibliographical note
Funding Information:This study was supported by the European Research Council (Advanced Grants 322920 and 833598), I-CORE Programs of the Planning and Budgeting Committee and The Israel Science Foundation (grants 1796/12 and 41/1), and the Israel Science Foundation administered by the Israeli Academy for Sciences and Humanities (grant 876/17). Y.E.G. was partially supported by the Hoffman Foundation. We thank T. Bamberger, D. Rabinovich, and M. Kournos for technical help; Y. Altuvia for fruitful discussions; E. Romm for graphical help; and S. Altuvia, A. Peer, S.P. Mizrahi, A. Bar, and M. Nitzan for helpful advice. Experimental Investigation, R.F.-R. M.B. and L.A.; Computational Analysis, R.F.-R. A.R. and Y.E.G.; Writing ? Original Draft, R.F.-R. and H.M.; Writing ? Review & Editing, R.F.-R. L.A. A.R. Y.E.G. M.B. and H.M.; Supervision, H.M. The authors declare no competing interests.
Funding Information:
This study was supported by the European Research Council (Advanced Grants 322920 and 833598 ), I-CORE Programs of the Planning and Budgeting Committee and The Israel Science Foundation (grants 1796/12 and 41/1 ), and the Israel Science Foundation administered by the Israeli Academy for Sciences and Humanities (grant 876/17 ). Y.E.G. was partially supported by the Hoffman Foundation . We thank T. Bamberger, D. Rabinovich, and M. Kournos for technical help; Y. Altuvia for fruitful discussions; E. Romm for graphical help; and S. Altuvia, A. Peer, S.P. Mizrahi, A. Bar, and M. Nitzan for helpful advice.
Publisher Copyright:
© 2020 The Author(s)
Keywords
- Hfq
- RIL-seq
- RNA sequencing
- posttranscriptional regulation
- small RNAs