Hierarchy in Hfq Chaperon Occupancy of Small RNA Targets Plays a Major Role in Their Regulation

Raya Faigenbaum-Romm; Avichai Reich; Yair E. Gatt; Meshi Barsheshet; Liron Argaman; Hanah Margalit

doi:10.1016/j.celrep.2020.02.016

Hierarchy in Hfq Chaperon Occupancy of Small RNA Targets Plays a Major Role in Their Regulation

Raya Faigenbaum-Romm
, Avichai Reich
, Yair E. Gatt
, Meshi Barsheshet
, Liron Argaman
, Hanah Margalit^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Faigenbaum-Romm et al. analyze data of sRNA-target pairs and transcriptome measurements, revealing that only a subset of targets shows expression changes under overexpression of the sRNA. Analyzing various target features, they find that competition among targets over binding the chaperon Hfq plays a major role in the regulatory outcome.

Original language	English
Pages (from-to)	3127-3138.e6
Journal	Cell Reports
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.02.016
State	Published - 3 Mar 2020

Bibliographical note

Publisher Copyright:
© 2020 The Author(s)

Keywords

Hfq
posttranscriptional regulation
RIL-seq
RNA sequencing
small RNAs

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10.1016/j.celrep.2020.02.016

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abstract = "Faigenbaum-Romm et al. analyze data of sRNA-target pairs and transcriptome measurements, revealing that only a subset of targets shows expression changes under overexpression of the sRNA. Analyzing various target features, they find that competition among targets over binding the chaperon Hfq plays a major role in the regulatory outcome.",

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AU - Barsheshet, Meshi

AU - Argaman, Liron

AU - Margalit, Hanah

PY - 2020/3/3

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KW - Hfq

KW - posttranscriptional regulation

KW - RIL-seq

KW - RNA sequencing

KW - small RNAs

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ER -

Hierarchy in Hfq Chaperon Occupancy of Small RNA Targets Plays a Major Role in Their Regulation

Abstract

Bibliographical note

Keywords

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