HIF1α Allows Monocytes to Take a Breather during Sepsis

Derek W. Gilroy; Simon Yona

doi:10.1016/j.immuni.2015.02.016

HIF1α Allows Monocytes to Take a Breather during Sepsis

Derek W. Gilroy^*
, Simon Yona

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova etal. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties. How the immune system is negatively affected by sepsis is not fully understood. Biswas and colleagues show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.

Original language	English
Pages (from-to)	397-399
Number of pages	3
Journal	Immunity
Volume	42
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2015.02.016
State	Published - 17 Mar 2015
Externally published	Yes

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© 2015 Elsevier Inc.

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title = "HIF1α Allows Monocytes to Take a Breather during Sepsis",

abstract = "How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova etal. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties. How the immune system is negatively affected by sepsis is not fully understood. Biswas and colleagues show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.",

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AU - Yona, Simon

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N2 - How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova etal. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties. How the immune system is negatively affected by sepsis is not fully understood. Biswas and colleagues show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.

AB - How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova etal. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties. How the immune system is negatively affected by sepsis is not fully understood. Biswas and colleagues show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.

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HIF1α Allows Monocytes to Take a Breather during Sepsis

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