High-fat diet protects the blood–brain barrier in an Alzheimer's disease mouse model

Shirin Elhaik Goldman, David Goez, David Last, Sharone Naor, Sigal Liraz Zaltsman, Inbal Sharvit-Ginon, Dana Atrakchi-Baranes, Chen Shemesh, Rachel Twitto-Greenberg, Shoval Tsach, Roni Lotan, Alicia Leikin-Frenkel, Aviv Shish, Yael Mardor, Michal Schnaider Beeri, Itzik Cooper*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease (AD). There is evidence for impaired blood–brain barrier (BBB) in both diseases, but its role in the interplay between them is not clear. Here, we investigated the effects of high-fat diet (HFD), a model for T2D, on the Tg2576 mouse model of AD, in regard to BBB function. We showed that HFD mice had higher weight, more insulin resistance, and higher serum HDL cholesterol levels, primarily in Tg2576 mice, which also had higher brain lipids content. In terms of behavior, Tg2576 HFD mice were less active and more anxious, but had better learning in the Morris Water Maze compared to Tg2576 on regular diet. HFD had no effect on the level of amyloid beta 1–42 in the cortex of Tg2576 mice, but increased the transcription level of insulin receptor in the hippocampus. Tg2576 mice on regular diet demonstrated more BBB disruption at 8 and 12 months accompanied by larger lateral ventricles volume in contrast to Tg2576 HFD mice, whose BBB leakage and ventricular volume were similar to wild-type (WT) mice. Our results suggest that in AD, HFD may promote better cognitive function through improvements of BBB function and of brain atrophy but not of amyloid beta levels. Lipid metabolism in the CNS and peripheral tissues and brain insulin signaling may underlie this protection.

Original languageAmerican English
Article numbere12818
JournalAging Cell
Volume17
Issue number5
DOIs
StatePublished - Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Keywords

  • Alzheimer’s disease
  • MRI
  • Tg2576 mice
  • amyloid beta
  • blood–brain barrier
  • cholesterol
  • high-fat diet
  • insulin resistance

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