High on food: the interaction between the neural circuits for feeding and for reward

Jing Jing Liu, Diptendu Mukherjee, Doron Haritan, Bogna Ignatowska-Jankowska, Ji Liu, Ami Citri, Zhiping P. Pang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Hunger, mostly initiated by a deficiency in energy, induces food seeking and intake. However, the drive toward food is not only regulated by physiological needs, but is motivated by the pleasure derived from ingestion of food, in particular palatable foods. Therefore, feeding is viewed as an adaptive motivated behavior that involves integrated communication between homeostatic feeding circuits and reward circuits. The initiation and termination of a feeding episode are instructed by a variety of neuronal signals, and maladaptive plasticity in almost any component of the network may lead to the development of pathological eating disorders. In this review we will summarize the latest understanding of how the feeding circuits and reward circuits in the brain interact. We will emphasize communication between the hypothalamus and the mesolimbic dopamine system and highlight complexities, discrepancies, open questions and future directions for the field.

Original languageAmerican English
Pages (from-to)165-176
Number of pages12
JournalFrontiers in Biology
Issue number2
StatePublished - 1 Apr 2015

Bibliographical note

Publisher Copyright:
© 2015, Higher Education Press and Springer-Verlag Berlin Heidelberg.


  • dopamine
  • feeding
  • hedonic
  • hypothalamus
  • mesolimbic system
  • neural circuitry
  • reward


Dive into the research topics of 'High on food: the interaction between the neural circuits for feeding and for reward'. Together they form a unique fingerprint.

Cite this