TY - JOUR
T1 - High prevalence of acquired cancer-related mutations in 146 human pluripotent stem cell lines and their differentiated derivatives
AU - Lezmi, Elyad
AU - Jung, Jonathan
AU - Benvenisty, Nissim
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.
PY - 2024/11
Y1 - 2024/11
N2 - To survey cancer-related mutations in human pluripotent stem cells and their derivatives, we analyzed >2,200 transcriptomes from 146 independent lines in the NCBI’s Sequence Read Archive. Twenty-two per cent of samples had at least one cancer-related mutation; of these, 64% had TP53 mutations, which conferred a pronounced selective advantage, perturbed target gene expression and altered cellular differentiation. These findings underscore the need for robust surveillance of cancer-related mutations in pluripotent cells, especially in clinical applications.
AB - To survey cancer-related mutations in human pluripotent stem cells and their derivatives, we analyzed >2,200 transcriptomes from 146 independent lines in the NCBI’s Sequence Read Archive. Twenty-two per cent of samples had at least one cancer-related mutation; of these, 64% had TP53 mutations, which conferred a pronounced selective advantage, perturbed target gene expression and altered cellular differentiation. These findings underscore the need for robust surveillance of cancer-related mutations in pluripotent cells, especially in clinical applications.
UR - http://www.scopus.com/inward/record.url?scp=85181667551&partnerID=8YFLogxK
U2 - 10.1038/s41587-023-02090-2
DO - 10.1038/s41587-023-02090-2
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C2 - 38195986
AN - SCOPUS:85181667551
SN - 1087-0156
VL - 42
SP - 1667
EP - 1671
JO - Nature Biotechnology
JF - Nature Biotechnology
IS - 11
ER -
