High-resolution NMR "chromatography" using a liquids spectrometer

Roy E. Hoffman*, Hilla Arzuan, Chava Pemberton, Abraham Aserin, Nissim Garti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

NMR spectroscopy is an excellent tool for the structural analysis of pure compounds. However, for mixtures it performs poorly because of overlapping signals. Diffusion can be used to separate compounds of widely differing molecular weight but the amount of separation is usually insufficient. Addition of a solid medium, analogous to the stationary phase in chromatography, can preferentially slow the diffusion of some components of a mixture permitting separation in the diffusion dimension. However, this would usually require a solid-state NMR spectrometer otherwise the signals would be too broad. Susceptibility matching the solvent to the solid medium yields a spectrum with narrow signals allowing the measurement of a DOSY spectrum with enhanced separation in the diffusion dimension.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalJournal of Magnetic Resonance
Volume194
Issue number2
DOIs
StatePublished - Oct 2008

Keywords

  • Diffusion
  • DOSY
  • Magnetic susceptibility
  • NMR chromatography
  • Silica

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