High-resolution STM imaging of novel poly(G)-poly(C) DNA molecules

Errez Shapir, Hezy Cohen, Natalia Borovok, Alexander B. Kotlyar*, Danny Porath

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

High-resolution scanning tunneling microscopy (STM) imaging of single double-stranded poly(G)-poly(C) DNA molecules, made by a novel synthesis method, shows the molecules morphology. The STM images reveal a periodic structure of ∼4 nm, seen as repeating "bulbs" along the molecules. These "bulbs" are associated with the molecule helix (the major grooves). "Nicks", two per 100 nm on the average, are observed along the DNA as well. The STM measurements were supported by a morphological statistics of the DNA molecule groove length and apparent height relative to the surface.

Original languageAmerican English
Pages (from-to)4430-4433
Number of pages4
JournalJournal of Physical Chemistry B
Volume110
Issue number9
DOIs
StatePublished - 9 Mar 2006

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