Highly efficient detector of the neurotransmitter ACh and AChE inhibitors

Ilya Goykhman*, Nina Korbakov, Carmen Bartic, Gustaaf Borghs, Micha E. Spira, Josef Shappir, Shlomo Yitzchaik

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Among the variety of applications for biosensors one of the exciting frontiers is to utilize those devices as post-synaptic sensing elements in chemical coupling between neurons and solid-state systems. The first necessary step to attain this challenge is to realize highly efficient detector for neurotransmitter acetylcholine (ACh). Herein, we demonstrate that the combination of floating gate configuration of ion-sensitive field effect transistor (ISFET) together with diluted covalent anchoring of enzyme acetylcholinesterase (AChE) onto device sensing area reveals a remarkable improvement of a four orders of magnitude in dose response to ACh. This high range sensitivity in addition to the benefits of peculiar microelectronic design show, that the presented hybrid provides a competent platform for assembly of artificial chemical synapse junction. Furthermore, our system exhibits clear response to eserine, a competitive inhibitor of AChE, and therefore it can be implemented as an effective sensor of pharmacological reagents, organophosphates, and nerve gases as well.

Original languageAmerican English
Pages (from-to)35-42
Number of pages8
JournalMaterials Research Society Symposium - Proceedings
StatePublished - 2007
EventMaterials Research Society Symposium Proceedings - Advanced Materials for Neuroprosthetic Interfaces - San Francisco, CA, United States
Duration: 9 Apr 200713 Apr 2007


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