Highly transmissible cytoplasmic incompatibility by the extracellular insect symbiont Spiroplasma

Marie Pollmann, Logan D. Moore, Elena Krimmer, Paul D'Alvise, Martin Hasselmann, Steve J. Perlman, Matthew J. Ballinger, Johannes L.M. Steidle*, Yuval Gottlieb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Cytoplasmic incompatibility (CI) is a form of reproductive manipulation caused by maternally inherited endosymbionts infecting arthropods, like Wolbachia, whereby matings between infected males and uninfected females produce few or no offspring. We report the discovery of a new CI symbiont, a strain of Spiroplasma causing CI in the parasitoid wasp Lariophagus distinguendus. Its extracellular occurrence enabled us to establish CI in uninfected adult insects by transferring Spiroplasma-infected hemolymph. We sequenced the CI-Spiroplasma genome and did not find any homologues of any of the cif genes discovered to cause CI in Wolbachia, suggesting independent evolution of CI. Instead, the genome contains other potential CI-causing candidate genes, such as homologues of high-mobility group (HMG) box proteins that are crucial in eukaryotic development but rare in bacterial genomes. Spiroplasma's extracellular nature and broad host range encompassing medically and agriculturally important arthropods make it a promising tool to study CI and its applications.

Original languageAmerican English
Article number104335
JournaliScience
Volume25
Issue number5
DOIs
StatePublished - 20 May 2022

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

Keywords

  • Entomology
  • Microbiology
  • Microbiology parasite
  • Zoology

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