TY - JOUR
T1 - Hip arthroplasty in patients with Gaucher disease
AU - Lebel, Ehud
AU - Ioscovich, Alexander
AU - Itzchaki, Menachem
AU - Zimran, Ari
AU - Elstein, Deborah
PY - 2011/1/15
Y1 - 2011/1/15
N2 - Patients with Gaucher disease suffering from the consequences of femoral head osteonecrosis deserve a treatment modality that will eliminate pain, preserve ambulation and hopefully will endure long enough to allow satisfactory daily life. Total hip arthroplasty fulfills these 3 objectives. The rate of complications during anesthesia and during surgical procedure is comparable to otherwise healthy population if the Gaucher patients are carefully evaluated pre-surgery and prepared by a medical team familiar with all aspects of the disease. With prompt preparation, meticulous procedure, and careful post-operative care, patients with Gaucher disease may benefit from long-lasting hip prostheses. It is to be hoped that newer types of implants would allow longer revision-free periods even in this young patient population who have developed avascular necrosis, and a greater hope for patients with Gaucher disease would be that early administration of bone-specific therapies may prevent osteonecrosis.
AB - Patients with Gaucher disease suffering from the consequences of femoral head osteonecrosis deserve a treatment modality that will eliminate pain, preserve ambulation and hopefully will endure long enough to allow satisfactory daily life. Total hip arthroplasty fulfills these 3 objectives. The rate of complications during anesthesia and during surgical procedure is comparable to otherwise healthy population if the Gaucher patients are carefully evaluated pre-surgery and prepared by a medical team familiar with all aspects of the disease. With prompt preparation, meticulous procedure, and careful post-operative care, patients with Gaucher disease may benefit from long-lasting hip prostheses. It is to be hoped that newer types of implants would allow longer revision-free periods even in this young patient population who have developed avascular necrosis, and a greater hope for patients with Gaucher disease would be that early administration of bone-specific therapies may prevent osteonecrosis.
KW - Arthroplasty
KW - Avascular necrosis
KW - Enzyme replacement therapy
KW - Gaucher disease
KW - Hip replacement
UR - http://www.scopus.com/inward/record.url?scp=78650831635&partnerID=8YFLogxK
U2 - 10.1016/j.bcmd.2010.09.001
DO - 10.1016/j.bcmd.2010.09.001
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C2 - 21056932
AN - SCOPUS:78650831635
SN - 1079-9796
VL - 46
SP - 60
EP - 65
JO - Blood Cells, Molecules, and Diseases
JF - Blood Cells, Molecules, and Diseases
IS - 1
ER -