Hip arthroplasty in patients with Gaucher disease

Ehud Lebel, Alexander Ioscovich, Menachem Itzchaki, Ari Zimran, Deborah Elstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Patients with Gaucher disease suffering from the consequences of femoral head osteonecrosis deserve a treatment modality that will eliminate pain, preserve ambulation and hopefully will endure long enough to allow satisfactory daily life. Total hip arthroplasty fulfills these 3 objectives. The rate of complications during anesthesia and during surgical procedure is comparable to otherwise healthy population if the Gaucher patients are carefully evaluated pre-surgery and prepared by a medical team familiar with all aspects of the disease. With prompt preparation, meticulous procedure, and careful post-operative care, patients with Gaucher disease may benefit from long-lasting hip prostheses. It is to be hoped that newer types of implants would allow longer revision-free periods even in this young patient population who have developed avascular necrosis, and a greater hope for patients with Gaucher disease would be that early administration of bone-specific therapies may prevent osteonecrosis.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalBlood Cells, Molecules, and Diseases
Volume46
Issue number1
DOIs
StatePublished - 15 Jan 2011
Externally publishedYes

Keywords

  • Arthroplasty
  • Avascular necrosis
  • Enzyme replacement therapy
  • Gaucher disease
  • Hip replacement

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