This chapter addresses the latest evidence regarding the involvement of histamine and histamine receptors in cancer development and progression with particular attention to H4R. The expression of H4R in different cell lines, the signal transduction pathways and biological responses associated with H4R as well as the in vivo treatment of experimental tumours with H4R ligands will be reviewed. The controversial aspects of histaminergic involvement in gastrointestinal physiopathology will be discussed, with particular reference to gastric mucosal damage and intestinal inflammation. In addition, the existing evidence of the presence of mast cells in human and murine lung cancer and the effect of histamine and other mast cell derived mediators in this cancer will be presented. Recent fndings support the therapeutic potential of H4R ligands in melanoma, breast, colon, pancreatic and lung cancer and the exploitation of the H4R as a molecular target for novel approaches in the treatment of cancer.
|Title of host publication
|Histamine H4 Receptor
|Subtitle of host publication
|A Novel Drug Target in Immunoregulation and Inflammation
|Number of pages
|Published - 1 Nov 2013
Bibliographical notePublisher Copyright:
Copyright © 2013 Holger Stark.