Histamine in cancer

Vanina A. Medina; Gabriella Coruzzi; Diego J.Martinel Lamas; Noelia Massari; Maristella Adami; Francesca Levi-Schaffer; Micha Ben-Zimra; Hubert Schwelberger; Elena S. Rivera

doi:10.2478/9788376560564.c8

Histamine in cancer

Vanina A. Medina, Gabriella Coruzzi, Diego J.Martinel Lamas, Noelia Massari, Maristella Adami, Francesca Levi-Schaffer, Micha Ben-Zimra, Hubert Schwelberger, Elena S. Rivera

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

10 Scopus citations

Abstract

This chapter addresses the latest evidence regarding the involvement of histamine and histamine receptors in cancer development and progression with particular attention to H₄R. The expression of H₄R in different cell lines, the signal transduction pathways and biological responses associated with H₄R as well as the in vivo treatment of experimental tumours with H₄R ligands will be reviewed. The controversial aspects of histaminergic involvement in gastrointestinal physiopathology will be discussed, with particular reference to gastric mucosal damage and intestinal inflammation. In addition, the existing evidence of the presence of mast cells in human and murine lung cancer and the effect of histamine and other mast cell derived mediators in this cancer will be presented. Recent fndings support the therapeutic potential of H₄R ligands in melanoma, breast, colon, pancreatic and lung cancer and the exploitation of the H₄R as a molecular target for novel approaches in the treatment of cancer.

Original language	English
Title of host publication	Histamine H4 Receptor
Subtitle of host publication	A Novel Drug Target in Immunoregulation and Inflammation
Publisher	Versita
Pages	259-308
Number of pages	50
Volume	9788376560564
ISBN (Electronic)	9788376560564
ISBN (Print)	8376560557, 9788376560557
DOIs	https://doi.org/10.2478/9788376560564.c8
State	Published - 1 Nov 2013

Bibliographical note

Publisher Copyright:
Copyright © 2013 Holger Stark.

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10.2478/9788376560564.c8

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abstract = "This chapter addresses the latest evidence regarding the involvement of histamine and histamine receptors in cancer development and progression with particular attention to H4R. The expression of H4R in different cell lines, the signal transduction pathways and biological responses associated with H4R as well as the in vivo treatment of experimental tumours with H4R ligands will be reviewed. The controversial aspects of histaminergic involvement in gastrointestinal physiopathology will be discussed, with particular reference to gastric mucosal damage and intestinal inflammation. In addition, the existing evidence of the presence of mast cells in human and murine lung cancer and the effect of histamine and other mast cell derived mediators in this cancer will be presented. Recent fndings support the therapeutic potential of H4R ligands in melanoma, breast, colon, pancreatic and lung cancer and the exploitation of the H4R as a molecular target for novel approaches in the treatment of cancer.",

author = "Medina, {Vanina A.} and Gabriella Coruzzi and Lamas, {Diego J.Martinel} and Noelia Massari and Maristella Adami and Francesca Levi-Schaffer and Micha Ben-Zimra and Hubert Schwelberger and Rivera, {Elena S.}",

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AU - Coruzzi, Gabriella

AU - Lamas, Diego J.Martinel

AU - Massari, Noelia

AU - Adami, Maristella

AU - Levi-Schaffer, Francesca

AU - Ben-Zimra, Micha

AU - Schwelberger, Hubert

AU - Rivera, Elena S.

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AB - This chapter addresses the latest evidence regarding the involvement of histamine and histamine receptors in cancer development and progression with particular attention to H4R. The expression of H4R in different cell lines, the signal transduction pathways and biological responses associated with H4R as well as the in vivo treatment of experimental tumours with H4R ligands will be reviewed. The controversial aspects of histaminergic involvement in gastrointestinal physiopathology will be discussed, with particular reference to gastric mucosal damage and intestinal inflammation. In addition, the existing evidence of the presence of mast cells in human and murine lung cancer and the effect of histamine and other mast cell derived mediators in this cancer will be presented. Recent fndings support the therapeutic potential of H4R ligands in melanoma, breast, colon, pancreatic and lung cancer and the exploitation of the H4R as a molecular target for novel approaches in the treatment of cancer.

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Histamine in cancer

Abstract

Bibliographical note

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