Histone Dimers: A Fundamental Unit In Histone Assembly

Ruth Sperling, Michael Bustin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Histone interactions which occur, at moderate ionic strengths, when several types of purified, renatured histones are mixed at equimolar ratios have been studied. The four histones H2A, H2B, H3 and H4 complex and form dimers. Histone H1 does not interact with the other four histone types and does not form dimers. Mixing of single histone species with preformed histone pairs as well as mixing of two different types of histone pairs, leads to exchange of histones among the pairs and formation of dimers. No trimers are formed. The dimers are in equilibrium with high-molecular weight histone structures.

Original languageEnglish
Pages (from-to)1263-1276
Number of pages14
JournalNucleic Acids Research
Volume3
Issue number5
DOIs
StatePublished - May 1976
Externally publishedYes

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