Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine

Philip L. McCarthy*, Ora Paltiel, Elena Maslova, Sergei Kulikov, Theresa Hahn, Kenneth J. Kopecky, Vera Drozdova, Natalya Shmatina, Ludmilla Tichonova, Jack Van Hoff, Inna Gavrilova, Howard Weinstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Seven morphologists examined 382 slide and 82 non-slide, post-Chernobyl pediatric acute leukemia (AL) cases in radiation-exposed areas of Belarus, Russia and Ukraine; part of a case-control study by the International Consortium for Research on the Health Effects of Radiation. Among the slide cases, 99% were confirmed as AL: 92% acute lymphoid leukemia (ALL) and 86% acute myeloid leukemia (AMD demonstrating the utility of FAB classification for distinguishing ALL and AML. Among the non-slide cases, 79% were confirmed as AL: 84% ALL, and 71% AML. This study affirms AL diagnostic accuracy during a time of social upheaval in the former Soviet Union.

Original languageAmerican English
Pages (from-to)1273-1280
Number of pages8
JournalLeukemia Research
Volume28
Issue number12
DOIs
StatePublished - Dec 2004
Externally publishedYes

Bibliographical note

Funding Information:
The authors would like to thank the members of the International Consortium for Research on the Health Effects of Radiation (ICRHER) who participated in the design and implementation of the Leukemia Case Control Study as well as the ICRHER Board and Scientific Review Committee. In particular, we acknowledge Drs. David Becker, Alexandra Bondar, Andre Bouville, Antone Brooks, Tatiana Chegerova, Nicholas Daniak, Scott Davis, Robert Day, Karen Falkner, Stuart Finch, Shirley Fry, Oleg Gvozd, Martin Mahoney, Arthur Michalek, Kirsten Moysich, Andrei Noschenko, Vlad Ostapenko, Leif Peterson, Alena Pryshchepava, Nicolai Rivkind, Nikita Schklovski-Kordi, Valeri Shevchuk, Jack Schull, Valeri Stepanenko, Arthur Upton, Paul Voilleque, Andrei Vorobiov, P Zamostyan who were involved in the planning, implementation and oversight of the ICRHER leukemia case control study. We especially wish to acknowledge the late Admiral Elmo Zumwalt, who was the driving force behind the ICRHER. In addition, the authors wish to acknowledge the expert editorial assistance and logistical support of Ms. Dorothy Macchio and Colonels (ret.) Dick McDonald and Mike Spiro. This work was supported by Grant # 00014-00-1-0898 issued to Georgetown University from the Office of Naval Research in support of the International Consortium for Research on the Health Effects of Radiation. The contents are solely the responsibility of the authors and do not necessarily represent the views of the Office of Naval Research or Georgetown University.

Keywords

  • AL
  • ALL
  • ALLU
  • ALU
  • AML
  • AMLU
  • CML
  • FAB
  • French-American-British
  • acute leukemia
  • acute leukemia, unclassified
  • acute lymphoid leukemia
  • acute lymphoid leukemia, unclassified
  • acute myeloid leukemia
  • acute myeloid leukemia, unclassified
  • chronic myeloid leukemia

Fingerprint

Dive into the research topics of 'Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine'. Together they form a unique fingerprint.

Cite this