Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine

Philip L. McCarthy; Ora Paltiel; Elena Maslova; Sergei Kulikov; Theresa Hahn; Kenneth J. Kopecky; Vera Drozdova; Natalya Shmatina; Ludmilla Tichonova; Jack Van Hoff; Inna Gavrilova; Howard Weinstein

doi:10.1016/j.leukres.2004.04.008

Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine

Philip L. McCarthy^*, Ora Paltiel, Elena Maslova, Sergei Kulikov, Theresa Hahn, Kenneth J. Kopecky, Vera Drozdova, Natalya Shmatina, Ludmilla Tichonova, Jack Van Hoff, Inna Gavrilova, Howard Weinstein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Seven morphologists examined 382 slide and 82 non-slide, post-Chernobyl pediatric acute leukemia (AL) cases in radiation-exposed areas of Belarus, Russia and Ukraine; part of a case-control study by the International Consortium for Research on the Health Effects of Radiation. Among the slide cases, 99% were confirmed as AL: 92% acute lymphoid leukemia (ALL) and 86% acute myeloid leukemia (AMD demonstrating the utility of FAB classification for distinguishing ALL and AML. Among the non-slide cases, 79% were confirmed as AL: 84% ALL, and 71% AML. This study affirms AL diagnostic accuracy during a time of social upheaval in the former Soviet Union.

Original language	English
Pages (from-to)	1273-1280
Number of pages	8
Journal	Leukemia Research
Volume	28
Issue number	12
DOIs	https://doi.org/10.1016/j.leukres.2004.04.008
State	Published - Dec 2004
Externally published	Yes

Bibliographical note

Funding Information:
The authors would like to thank the members of the International Consortium for Research on the Health Effects of Radiation (ICRHER) who participated in the design and implementation of the Leukemia Case Control Study as well as the ICRHER Board and Scientific Review Committee. In particular, we acknowledge Drs. David Becker, Alexandra Bondar, Andre Bouville, Antone Brooks, Tatiana Chegerova, Nicholas Daniak, Scott Davis, Robert Day, Karen Falkner, Stuart Finch, Shirley Fry, Oleg Gvozd, Martin Mahoney, Arthur Michalek, Kirsten Moysich, Andrei Noschenko, Vlad Ostapenko, Leif Peterson, Alena Pryshchepava, Nicolai Rivkind, Nikita Schklovski-Kordi, Valeri Shevchuk, Jack Schull, Valeri Stepanenko, Arthur Upton, Paul Voilleque, Andrei Vorobiov, P Zamostyan who were involved in the planning, implementation and oversight of the ICRHER leukemia case control study. We especially wish to acknowledge the late Admiral Elmo Zumwalt, who was the driving force behind the ICRHER. In addition, the authors wish to acknowledge the expert editorial assistance and logistical support of Ms. Dorothy Macchio and Colonels (ret.) Dick McDonald and Mike Spiro. This work was supported by Grant # 00014-00-1-0898 issued to Georgetown University from the Office of Naval Research in support of the International Consortium for Research on the Health Effects of Radiation. The contents are solely the responsibility of the authors and do not necessarily represent the views of the Office of Naval Research or Georgetown University.

Keywords

AL
ALL
ALLU
ALU
AML
AMLU
CML
FAB
French-American-British
acute leukemia
acute leukemia, unclassified
acute lymphoid leukemia
acute lymphoid leukemia, unclassified
acute myeloid leukemia
acute myeloid leukemia, unclassified
chronic myeloid leukemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.leukres.2004.04.008

Cite this

McCarthy, P. L., Paltiel, O., Maslova, E., Kulikov, S., Hahn, T., Kopecky, K. J., Drozdova, V., Shmatina, N., Tichonova, L., Van Hoff, J., Gavrilova, I., & Weinstein, H. (2004). Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine. Leukemia Research, 28(12), 1273-1280. https://doi.org/10.1016/j.leukres.2004.04.008

@article{3f35aa0f1452407cbe3069740f9d30d0,

title = "Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine",

abstract = "Seven morphologists examined 382 slide and 82 non-slide, post-Chernobyl pediatric acute leukemia (AL) cases in radiation-exposed areas of Belarus, Russia and Ukraine; part of a case-control study by the International Consortium for Research on the Health Effects of Radiation. Among the slide cases, 99% were confirmed as AL: 92% acute lymphoid leukemia (ALL) and 86% acute myeloid leukemia (AMD demonstrating the utility of FAB classification for distinguishing ALL and AML. Among the non-slide cases, 79% were confirmed as AL: 84% ALL, and 71% AML. This study affirms AL diagnostic accuracy during a time of social upheaval in the former Soviet Union.",

keywords = "AL, ALL, ALLU, ALU, AML, AMLU, CML, FAB, French-American-British, acute leukemia, acute leukemia, unclassified, acute lymphoid leukemia, acute lymphoid leukemia, unclassified, acute myeloid leukemia, acute myeloid leukemia, unclassified, chronic myeloid leukemia",

author = "McCarthy, {Philip L.} and Ora Paltiel and Elena Maslova and Sergei Kulikov and Theresa Hahn and Kopecky, {Kenneth J.} and Vera Drozdova and Natalya Shmatina and Ludmilla Tichonova and {Van Hoff}, Jack and Inna Gavrilova and Howard Weinstein",

note = "Funding Information: The authors would like to thank the members of the International Consortium for Research on the Health Effects of Radiation (ICRHER) who participated in the design and implementation of the Leukemia Case Control Study as well as the ICRHER Board and Scientific Review Committee. In particular, we acknowledge Drs. David Becker, Alexandra Bondar, Andre Bouville, Antone Brooks, Tatiana Chegerova, Nicholas Daniak, Scott Davis, Robert Day, Karen Falkner, Stuart Finch, Shirley Fry, Oleg Gvozd, Martin Mahoney, Arthur Michalek, Kirsten Moysich, Andrei Noschenko, Vlad Ostapenko, Leif Peterson, Alena Pryshchepava, Nicolai Rivkind, Nikita Schklovski-Kordi, Valeri Shevchuk, Jack Schull, Valeri Stepanenko, Arthur Upton, Paul Voilleque, Andrei Vorobiov, P Zamostyan who were involved in the planning, implementation and oversight of the ICRHER leukemia case control study. We especially wish to acknowledge the late Admiral Elmo Zumwalt, who was the driving force behind the ICRHER. In addition, the authors wish to acknowledge the expert editorial assistance and logistical support of Ms. Dorothy Macchio and Colonels (ret.) Dick McDonald and Mike Spiro. This work was supported by Grant # 00014-00-1-0898 issued to Georgetown University from the Office of Naval Research in support of the International Consortium for Research on the Health Effects of Radiation. The contents are solely the responsibility of the authors and do not necessarily represent the views of the Office of Naval Research or Georgetown University. ",

year = "2004",

month = dec,

doi = "10.1016/j.leukres.2004.04.008",

language = "אנגלית",

volume = "28",

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journal = "Leukemia Research",

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McCarthy, PL, Paltiel, O, Maslova, E, Kulikov, S, Hahn, T, Kopecky, KJ, Drozdova, V, Shmatina, N, Tichonova, L, Van Hoff, J, Gavrilova, I & Weinstein, H 2004, 'Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine', Leukemia Research, vol. 28, no. 12, pp. 1273-1280. https://doi.org/10.1016/j.leukres.2004.04.008

TY - JOUR

T1 - Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine

AU - McCarthy, Philip L.

AU - Paltiel, Ora

AU - Maslova, Elena

AU - Kulikov, Sergei

AU - Hahn, Theresa

AU - Kopecky, Kenneth J.

AU - Drozdova, Vera

AU - Shmatina, Natalya

AU - Tichonova, Ludmilla

AU - Van Hoff, Jack

AU - Gavrilova, Inna

AU - Weinstein, Howard

N1 - Funding Information: The authors would like to thank the members of the International Consortium for Research on the Health Effects of Radiation (ICRHER) who participated in the design and implementation of the Leukemia Case Control Study as well as the ICRHER Board and Scientific Review Committee. In particular, we acknowledge Drs. David Becker, Alexandra Bondar, Andre Bouville, Antone Brooks, Tatiana Chegerova, Nicholas Daniak, Scott Davis, Robert Day, Karen Falkner, Stuart Finch, Shirley Fry, Oleg Gvozd, Martin Mahoney, Arthur Michalek, Kirsten Moysich, Andrei Noschenko, Vlad Ostapenko, Leif Peterson, Alena Pryshchepava, Nicolai Rivkind, Nikita Schklovski-Kordi, Valeri Shevchuk, Jack Schull, Valeri Stepanenko, Arthur Upton, Paul Voilleque, Andrei Vorobiov, P Zamostyan who were involved in the planning, implementation and oversight of the ICRHER leukemia case control study. We especially wish to acknowledge the late Admiral Elmo Zumwalt, who was the driving force behind the ICRHER. In addition, the authors wish to acknowledge the expert editorial assistance and logistical support of Ms. Dorothy Macchio and Colonels (ret.) Dick McDonald and Mike Spiro. This work was supported by Grant # 00014-00-1-0898 issued to Georgetown University from the Office of Naval Research in support of the International Consortium for Research on the Health Effects of Radiation. The contents are solely the responsibility of the authors and do not necessarily represent the views of the Office of Naval Research or Georgetown University.

PY - 2004/12

Y1 - 2004/12

N2 - Seven morphologists examined 382 slide and 82 non-slide, post-Chernobyl pediatric acute leukemia (AL) cases in radiation-exposed areas of Belarus, Russia and Ukraine; part of a case-control study by the International Consortium for Research on the Health Effects of Radiation. Among the slide cases, 99% were confirmed as AL: 92% acute lymphoid leukemia (ALL) and 86% acute myeloid leukemia (AMD demonstrating the utility of FAB classification for distinguishing ALL and AML. Among the non-slide cases, 79% were confirmed as AL: 84% ALL, and 71% AML. This study affirms AL diagnostic accuracy during a time of social upheaval in the former Soviet Union.

AB - Seven morphologists examined 382 slide and 82 non-slide, post-Chernobyl pediatric acute leukemia (AL) cases in radiation-exposed areas of Belarus, Russia and Ukraine; part of a case-control study by the International Consortium for Research on the Health Effects of Radiation. Among the slide cases, 99% were confirmed as AL: 92% acute lymphoid leukemia (ALL) and 86% acute myeloid leukemia (AMD demonstrating the utility of FAB classification for distinguishing ALL and AML. Among the non-slide cases, 79% were confirmed as AL: 84% ALL, and 71% AML. This study affirms AL diagnostic accuracy during a time of social upheaval in the former Soviet Union.

KW - AL

KW - ALL

KW - ALLU

KW - ALU

KW - AML

KW - AMLU

KW - CML

KW - FAB

KW - French-American-British

KW - acute leukemia

KW - acute leukemia, unclassified

KW - acute lymphoid leukemia

KW - acute lymphoid leukemia, unclassified

KW - acute myeloid leukemia

KW - acute myeloid leukemia, unclassified

KW - chronic myeloid leukemia

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AN - SCOPUS:4744356100

SN - 0145-2126

VL - 28

SP - 1273

EP - 1280

JO - Leukemia Research

JF - Leukemia Research

IS - 12

ER -

Histopathologic verification of acute leukemia (AL) in a cohort of 463 post-Chernobyl patients from Belarus, Russia and Ukraine

Abstract

Bibliographical note

Keywords

UN SDGs

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