Histopathology and apoptosis in an animal model of reversible renal injury

Mony Shuvy*, Abraham Nyska, Ronen Beeri, Suzan Abedat, Anca Gal-Moscovici, Nalini M. Rajamannan, Chaim Lotan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


High adenine phosphate (HAP) diet serves as an animal model of chronic renal failure (RF). Induction of RF and establishment of end organ damage require long exposure periods to this diet. Previously, we have shown that RF is reversible after diet cessation even after protracted administration. In this study, we explored the underlying renal changes and cellular pathways occurring during administration and after cessation of the diet. Kidneys were obtained from rats fed HAP diet for 7 weeks, and from rats fed HAP diet followed a 10 week recovery period on normal diet. The kidneys of HAP diet group were significantly enlarged due to tubular injury characterized by massive cystic dilatation and crystal deposition. Kidney injury was associated with markers of apoptosis as well as with activation of apoptosis related pathways. Diet cessation was associated with a significant reduction in kidney size, tubules diameter, and crystals deposition. The recovery from renal injury was coupled with regression of apoptotic features. This is the first study showing the potential reversibility of long standing RF model, allowing optimal evaluation of uremia-chronic effects.

Original languageAmerican English
Pages (from-to)303-306
Number of pages4
JournalExperimental and Toxicologic Pathology
Issue number4
StatePublished - May 2011
Externally publishedYes

Bibliographical note

Funding Information:
The Chief Scientist Office of the Ministry of Health, Israel; The Berman Foundation for Cardiovascular Research of Hadassah Medical Center; The Joint Research Fund of the Hebrew University and Hadassah Medical Center.


  • Animal model
  • Apoptosis
  • Diet
  • Renal failure
  • Reversibility


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