HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens

Network for Genomic Surveillance in South Africa (NGS-SA); Will Fischer; Elena E. Giorgi; Srirupa Chakraborty; Kien Nguyen; Tanmoy Bhattacharya; James Theiler; Pablo A. Goloboff; Hyejin Yoon; Werner Abfalterer; Brian T. Foley; Houriiyah Tegally; James Emmanuel San; Tulio de Oliveira; Eduan Wilkinson; Nokukhanya Msomi; Arash Iranzadeh; Vagner Fonseca; Deelan Doolabh; Koleka Mlisana; Anne von Gottberg; Sibongile Walaza; Mushal Allam; Arshad Ismail; Thabo Mohale; Allison J. Glass; Susan Engelbrecht; Gert Van Zyl; Wolfgang Preiser; Francesco Petruccione; Alex Sigal; Diana Hardie; Gert Marais; Marvin Hsiao; Stephen Korsman; Mary Ann Davies; Lynn Tyers; Innocent Mudau; Denis York; Caroline Maslo; Dominique Goedhals; Shareef Abrahams; Oluwakemi Laguda-Akingba; Arghavan Alisoltani-Dehkordi; Adam Godzik; Constantinos Kurt Wibmer; Bryan Trevor Sewell; José Lourenço; Sergei L.Kosakovsky Pond; Steven Weaver; Marta Giovanetti

doi:10.1016/j.chom.2021.05.012

HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens

Network for Genomic Surveillance in South Africa (NGS-SA)
, Will Fischer
, Elena E. Giorgi
, Srirupa Chakraborty
, Kien Nguyen
, Tanmoy Bhattacharya
, James Theiler
, Pablo A. Goloboff
, Hyejin Yoon
, Werner Abfalterer
, Brian T. Foley
, Houriiyah Tegally
, James Emmanuel San
, Tulio de Oliveira
, Eduan Wilkinson
, Nokukhanya Msomi
, Arash Iranzadeh
, Vagner Fonseca
, Deelan Doolabh
, Koleka Mlisana

Anne von Gottberg, Sibongile Walaza, Mushal Allam, Arshad Ismail, Thabo Mohale, Allison J. Glass, Susan Engelbrecht, Gert Van Zyl, Wolfgang Preiser, Francesco Petruccione, Alex Sigal, Diana Hardie, Gert Marais, Marvin Hsiao, Stephen Korsman, Mary Ann Davies, Lynn Tyers, Innocent Mudau, Denis York, Caroline Maslo, Dominique Goedhals, Shareef Abrahams, Oluwakemi Laguda-Akingba, Arghavan Alisoltani-Dehkordi, Adam Godzik, Constantinos Kurt Wibmer, Bryan Trevor Sewell, José Lourenço, Sergei L.Kosakovsky Pond, Steven Weaver, Marta Giovanetti

Department of Immunology and Cancer Research

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.

Original language	English
Pages (from-to)	1093-1110
Number of pages	18
Journal	Cell Host and Microbe
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/j.chom.2021.05.012
State	Published - 14 Jul 2021

Bibliographical note

Publisher Copyright:
© 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV-1
SARS-CoV-2
evolution
glycosylation
immune escape
insertions and deletions
recombination

Access to Document

10.1016/j.chom.2021.05.012

Cite this

Network for Genomic Surveillance in South Africa (NGS-SA), Fischer, W., Giorgi, E. E., Chakraborty, S., Nguyen, K., Bhattacharya, T., Theiler, J., Goloboff, P. A., Yoon, H., Abfalterer, W., Foley, B. T., Tegally, H., San, J. E., de Oliveira, T., Wilkinson, E., Msomi, N., Iranzadeh, A., Fonseca, V., Doolabh, D., ... Giovanetti, M. (2021). HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens. Cell Host and Microbe, 29(7), 1093-1110. https://doi.org/10.1016/j.chom.2021.05.012

@article{213490df199e49c18df0ee8c5347facf,

title = "HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens",

abstract = "Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1{\textquoteright}s extraordinary diversity and SARS-CoV-2{\textquoteright}s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.",

keywords = "HIV-1, SARS-CoV-2, evolution, glycosylation, immune escape, insertions and deletions, recombination",

author = "\{Network for Genomic Surveillance in South Africa (NGS-SA)\} and Will Fischer and Giorgi, \{Elena E.\} and Srirupa Chakraborty and Kien Nguyen and Tanmoy Bhattacharya and James Theiler and Goloboff, \{Pablo A.\} and Hyejin Yoon and Werner Abfalterer and Foley, \{Brian T.\} and Houriiyah Tegally and San, \{James Emmanuel\} and \{de Oliveira\}, Tulio and Eduan Wilkinson and Nokukhanya Msomi and Arash Iranzadeh and Vagner Fonseca and Deelan Doolabh and Koleka Mlisana and \{von Gottberg\}, Anne and Sibongile Walaza and Mushal Allam and Arshad Ismail and Thabo Mohale and Glass, \{Allison J.\} and Susan Engelbrecht and \{Van Zyl\}, Gert and Wolfgang Preiser and Francesco Petruccione and Alex Sigal and Diana Hardie and Gert Marais and Marvin Hsiao and Stephen Korsman and Davies, \{Mary Ann\} and Lynn Tyers and Innocent Mudau and Denis York and Caroline Maslo and Dominique Goedhals and Shareef Abrahams and Oluwakemi Laguda-Akingba and Arghavan Alisoltani-Dehkordi and Adam Godzik and Wibmer, \{Constantinos Kurt\} and Sewell, \{Bryan Trevor\} and Jos{\'e} Louren{\c c}o and Pond, \{Sergei L.Kosakovsky\} and Steven Weaver and Marta Giovanetti",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = jul,

day = "14",

doi = "10.1016/j.chom.2021.05.012",

language = "אנגלית",

volume = "29",

pages = "1093--1110",

journal = "Cell Host and Microbe",

issn = "1931-3128",

publisher = "Cell Press",

number = "7",

}

Network for Genomic Surveillance in South Africa (NGS-SA), Fischer, W, Giorgi, EE, Chakraborty, S, Nguyen, K, Bhattacharya, T, Theiler, J, Goloboff, PA, Yoon, H, Abfalterer, W, Foley, BT, Tegally, H, San, JE, de Oliveira, T, Wilkinson, E, Msomi, N, Iranzadeh, A, Fonseca, V, Doolabh, D, Mlisana, K, von Gottberg, A, Walaza, S, Allam, M, Ismail, A, Mohale, T, Glass, AJ, Engelbrecht, S, Van Zyl, G, Preiser, W, Petruccione, F, Sigal, A, Hardie, D, Marais, G, Hsiao, M, Korsman, S, Davies, MA, Tyers, L, Mudau, I, York, D, Maslo, C, Goedhals, D, Abrahams, S, Laguda-Akingba, O, Alisoltani-Dehkordi, A, Godzik, A, Wibmer, CK, Sewell, BT, Lourenço, J, Pond, SLK, Weaver, S & Giovanetti, M 2021, 'HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens', Cell Host and Microbe, vol. 29, no. 7, pp. 1093-1110. https://doi.org/10.1016/j.chom.2021.05.012

TY - JOUR

T1 - HIV-1 and SARS-CoV-2

T2 - Patterns in the evolution of two pandemic pathogens

AU - Network for Genomic Surveillance in South Africa (NGS-SA)

AU - Fischer, Will

AU - Giorgi, Elena E.

AU - Chakraborty, Srirupa

AU - Nguyen, Kien

AU - Bhattacharya, Tanmoy

AU - Theiler, James

AU - Goloboff, Pablo A.

AU - Yoon, Hyejin

AU - Abfalterer, Werner

AU - Foley, Brian T.

AU - Tegally, Houriiyah

AU - San, James Emmanuel

AU - de Oliveira, Tulio

AU - Wilkinson, Eduan

AU - Msomi, Nokukhanya

AU - Iranzadeh, Arash

AU - Fonseca, Vagner

AU - Doolabh, Deelan

AU - Mlisana, Koleka

AU - von Gottberg, Anne

AU - Walaza, Sibongile

AU - Allam, Mushal

AU - Ismail, Arshad

AU - Mohale, Thabo

AU - Glass, Allison J.

AU - Engelbrecht, Susan

AU - Van Zyl, Gert

AU - Preiser, Wolfgang

AU - Petruccione, Francesco

AU - Sigal, Alex

AU - Hardie, Diana

AU - Marais, Gert

AU - Hsiao, Marvin

AU - Korsman, Stephen

AU - Davies, Mary Ann

AU - Tyers, Lynn

AU - Mudau, Innocent

AU - York, Denis

AU - Maslo, Caroline

AU - Goedhals, Dominique

AU - Abrahams, Shareef

AU - Laguda-Akingba, Oluwakemi

AU - Alisoltani-Dehkordi, Arghavan

AU - Godzik, Adam

AU - Wibmer, Constantinos Kurt

AU - Sewell, Bryan Trevor

AU - Lourenço, José

AU - Pond, Sergei L.Kosakovsky

AU - Weaver, Steven

AU - Giovanetti, Marta

PY - 2021/7/14

Y1 - 2021/7/14

N2 - Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.

AB - Humanity is currently facing the challenge of two devastating pandemics caused by two very different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which has swept the world in the course of a single year. The same evolutionary strategies that drive HIV-1 evolution are at play in SARS-CoV-2. Single nucleotide mutations, multi-base insertions and deletions, recombination, and variation in surface glycans all generate the variability that, guided by natural selection, enables both HIV-1’s extraordinary diversity and SARS-CoV-2’s slower pace of mutation accumulation. Even though SARS-CoV-2 diversity is more limited, recently emergent SARS-CoV-2 variants carry Spike mutations that have important phenotypic consequences in terms of both antibody resistance and enhanced infectivity. We review and compare how these mutational patterns manifest in these two distinct viruses to provide the variability that fuels their evolution by natural selection.

KW - HIV-1

KW - SARS-CoV-2

KW - evolution

KW - glycosylation

KW - immune escape

KW - insertions and deletions

KW - recombination

UR - https://www.scopus.com/pages/publications/85109605735

U2 - 10.1016/j.chom.2021.05.012

DO - 10.1016/j.chom.2021.05.012

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 34242582

AN - SCOPUS:85109605735

SN - 1931-3128

VL - 29

SP - 1093

EP - 1110

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 7

ER -

HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this