Hodgkin lymphoma patients in first remission: Routine positron emission tomography/computerized tomography imaging is not superior to clinical follow-up for patients with no residual mass

Eldad J. Dann*, Leanne Berkahn, Tatiana Mashiach, Michael Frumer, Ariel Agur, Bridgett Mcdiarmid, Rachel Bar-Shalom, Ora Paltiel, Neta Goldschmidt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Summary: There is no consensus regarding optimal follow-up mode for Hodgkin lymphoma (HL) patients that achieve complete remission following chemotherapy or combined chemo- and radiation therapy. Several studies demonstrated high sensitivity of positron emission tomography/computerized tomography (PET/CT) in detecting disease progression; however, these techniques are currently not recommended for routine follow-up. This retrospective study conducted in two Israeli (N = 291) and one New Zealand academic centres (N = 77), compared a group of HL patients, followed-up with routine imaging every 6 months during the first 2 years after achieving remission, once in the third year, with additional dedicated studies performed due to symptoms or physical findings (Group I) to a group of patients without residual masses who underwent clinically-based surveillance with dedicated imaging upon relapse suspicion (Group II). Five-year overall survival (OS) was 94% and median time to relapse was 8·6 months for both modes. Relapse rates in Groups I and II were 13% and 9%, respectively. During the first 3 years of follow-up, 47·5 and 4·7 studies were performed per detected relapse in Groups I and II, respectively. The current study demonstrated no benefit in either progression-free survival (PFS) or OS in HL patients followed by routine imaging versus clinical follow-up. The cost was 10 times higher for routine imaging.

Original languageAmerican English
Pages (from-to)694-700
Number of pages7
JournalBritish Journal of Haematology
Volume164
Issue number5
DOIs
StatePublished - Mar 2014
Externally publishedYes

Keywords

  • Clinical follow-up
  • Hodgkin lymphoma
  • Positron emission tomography/computerized tomography
  • Remission
  • Sensitivity

Fingerprint

Dive into the research topics of 'Hodgkin lymphoma patients in first remission: Routine positron emission tomography/computerized tomography imaging is not superior to clinical follow-up for patients with no residual mass'. Together they form a unique fingerprint.

Cite this