TY - JOUR
T1 - Host factors affecting the homologous and heterologous immune response of cattle to FMDV
T2 - Genetic background, age, virus strains and route of administration
AU - Samina, Itzchak
AU - Zakay-Rones, Zichria
AU - Weller, J. I.
AU - Peleg, Ben Ami
PY - 1998/2
Y1 - 1998/2
N2 - Sixty bulls were tested for antibodies to the heterologous serotype C1 of FMDV following repeatable vaccinations with a commercial trivalent vaccine (O1, A22, Asia1). Six (10%) bulls were found to possess rather high levels of heterologous neutralizing antibodies which showed accumulative trend with age. Two high positive and two negative bulls for the heterologous serotype C1 were selected for progeny test involving ten daughters of each bull. The four bulls, either positive or negative for the heterologous serotype C1, showed significant phenotypic correlation between their heterologous and homologous titers (O1, A22, Asia1). This correlation between heterologous and homologous antibody titers was not found in the daughters of these bulls. However, two of ten daughters of one positive bull, to C1 showed individual high titers (≤1.5). The intradermal (ID) as compared to subcutaneous (SC) route of administration resulted in higher rate of responders to both heterologous serotypes C1 and SAT1. The heterologous immune response to FMDV in Isreali-Friesian cattle was found to be related to the age of the host, multiplicity of vaccinations, route of vaccination, kind and numbers of the antigens used in the vaccin. The homologous response is also controlled by genetic factors.
AB - Sixty bulls were tested for antibodies to the heterologous serotype C1 of FMDV following repeatable vaccinations with a commercial trivalent vaccine (O1, A22, Asia1). Six (10%) bulls were found to possess rather high levels of heterologous neutralizing antibodies which showed accumulative trend with age. Two high positive and two negative bulls for the heterologous serotype C1 were selected for progeny test involving ten daughters of each bull. The four bulls, either positive or negative for the heterologous serotype C1, showed significant phenotypic correlation between their heterologous and homologous titers (O1, A22, Asia1). This correlation between heterologous and homologous antibody titers was not found in the daughters of these bulls. However, two of ten daughters of one positive bull, to C1 showed individual high titers (≤1.5). The intradermal (ID) as compared to subcutaneous (SC) route of administration resulted in higher rate of responders to both heterologous serotypes C1 and SAT1. The heterologous immune response to FMDV in Isreali-Friesian cattle was found to be related to the age of the host, multiplicity of vaccinations, route of vaccination, kind and numbers of the antigens used in the vaccin. The homologous response is also controlled by genetic factors.
KW - Cross-reactivity
KW - FMDV
KW - Genetic background
KW - Intradermal
UR - http://www.scopus.com/inward/record.url?scp=0032008091&partnerID=8YFLogxK
U2 - 10.1016/S0264-410X(97)00212-0
DO - 10.1016/S0264-410X(97)00212-0
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C2 - 9607052
AN - SCOPUS:0032008091
SN - 0264-410X
VL - 16
SP - 335
EP - 339
JO - Vaccine
JF - Vaccine
IS - 4
ER -