How Can Static and Oscillating Electric Fields Serve in Decomposing Alzheimer's and Other Senile Plaques?

Surajit Kalita, Hagai Bergman, Kshatresh Dutta Dubey*, Sason Shaik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Alzheimer's disease is one of the most common neurodegenerative conditions, which are ascribed to extracellular accumulation of β-amyloid peptides into plaques. This phenomenon seems to typify other related neurodegenerative diseases. The present study uses classical molecular-dynamics simulations to decipher the aggregation-disintegration behavior of β-amyloid peptide plaques in the presence of static and oscillating oriented external electric fields (OEEFs). A long-term disintegration of such plaques is highly desirable since this may improve the prospects of therapeutic treatments of Alzheimer's disease and of other neurodegenerative diseases typified by senile plaques. Our study illustrates the spontaneous aggregation of the β-amyloid, its prevention and breakdown when OEEF is applied, and the fate of the broken aggregate when the OEEF is removed. Notably, we demonstrate that the usage of an oscillating OEEF on β-amyloid aggregates appears to lead to an irreversible disintegration. Insight is provided into the root causes of the various modes of aggregation, as well as into the different fates of OEEF-induced disintegration in oscillating vs static fields. Finally, our simulation results are compared to the well-established TTFields and the Deep Brain Stimulation (DBS) therapies, which are currently used options for treatments of Alzheimer's disease and other related neurodegenerative diseases.

Original languageAmerican English
Pages (from-to)3543-3553
Number of pages11
JournalJournal of the American Chemical Society
Volume145
Issue number6
DOIs
StatePublished - 15 Feb 2023

Bibliographical note

Funding Information:
S.S. is supported by the ISF (Grant 520/18). K.D.D. acknowledges the Department of Biotechnology, Ministry of Science and Technology, Govt. of India for the Ramalingaswami Re-entry research grant (BT/RLF/Re-entry/10/2017). H.B. is supported by the ISF MAPATS program (Grant 1738/22).

Publisher Copyright:
© 2023 American Chemical Society.

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