How incorrect annotations evolve - The case of short ORFs

Michal Linial*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The draft of the human genome sequence is still incomplete. The outstanding tasks include filling in some gaps, finalizing the assembly of short sequences, improving sequence accuracy and correctly identifying coding regions. However, a closely related problem that receives little attention is the substantial number of incorrect annotations that have penetrated some of the widely used databases. This article illustrates this problem using the example of ubiquitin genes, and draws some conclusions that apply to false annotations in other short open reading frames (ORFs). Although the focus is on the human genome, other genomes are equally prone to similar propagation of false annotations.

Original languageAmerican English
Pages (from-to)298-300
Number of pages3
JournalTrends in Biotechnology
Issue number7
StatePublished - 1 Jul 2003

Bibliographical note

Funding Information:
M.L. is a member of the HUJI-Computational Biology Center; This study is supported by the Israeli Ministry of Defense.


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