HU308 Mitigates Osteoarthritis by Stimulating Sox9-Related Networks of Carbohydrate Metabolism

Keyphrases

• Carbohydrate Metabolism 100%
• SRY-box Transcription Factor 9 (SOX9) 100%
• Osteoarthritis 100%
• HU-308 100%
• Wild Mice 30%
• Cannabinoid Receptor 2 20%
• Gene Network 20%
• Human Chondrocytes 20%
• Null Mice 20%
• CNR2 20%
• CREB1 20%
• Joint Damage 20%
• Aging 10%
• Trauma 10%
• Quantitative PCR 10%
• Immobility 10%
• Mechanism of Action 10%
• Pain Sensitivity 10%
• Age-matched 10%
• Chromatin Immunoprecipitation (ChIP) 10%
• Patient Demographics 10%
• Structural Features 10%
• Systemic Administration 10%
• Age-related 10%
• Transcriptome Analysis 10%
• Transcriptional Activity 10%
• RNA Sequencing (RNA-seq) 10%
• Aged Mice 10%
• Articular Cartilage 10%
• Immunoblotting 10%
• COL2A1 10%
• Intraperitoneal Administration 10%
• Severity of Osteoarthritis 10%
• Time-related 10%
• Post-traumatic 10%
• Patient-derived 10%
• Synovitis 10%
• Severe Pain 10%
• Post-traumatic Osteoarthritis 10%
• Human Primary Chondrocytes 10%
• Joint Integrity 10%
• Intra-articular Administration 10%
• Intra-articular 10%

Medicine and Dentistry

• Carbohydrate Metabolism 100%
• Osteoarthritis 100%
• 4 [4 (1,1 Dimethylheptyl) 2,6 Dimethoxyphenyl] 6,6 dimethylbicyclo[3.1.1]hept 2 en 2 Ylmethanol 100%
• Chondrocyte 30%
• Cannabinoid Receptor 20%
• Immobility 10%
• Injury 10%
• Nociception 10%
• Intraperitoneal Drug Administration 10%
• Gene Expression Profiling 10%
• Systemic Administration 10%
• Immunoblotting 10%
• Identified Patient 10%
• Reverse Transcription Polymerase Chain Reaction 10%
• Articular Cartilage 10%
• RNA Sequence 10%
• Chromatin Immunoprecipitation 10%
• Synovitis 10%
• Joint Injection 10%