TY - JOUR
T1 - Human and porcine early kidney precursors as a new source for transplantation
AU - Dekel, Benjamin
AU - Burakova, Tatyana
AU - Arditti, Fabian D.
AU - Reich-Zeliger, Shlomit
AU - Milstein, Oren
AU - Aviel-Ronen, Sarit
AU - Rechavi, Gideon
AU - Friedman, Nir
AU - Kaminski, Naftali
AU - Passwell, Justen H.
AU - Reisner, Yair
N1 - Funding Information:
Acknowledgments Supported in part by a grant from Mrs. E. Drake and the Gabriella Rich Center for Transplantation Biology Research and the Edward H. Kass Award from the American Physicians Fellowship (B.D.). Y.R. holds the Henry H. Drake Professorial Chair in Immunology.
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation in mice reveals the earliest gestational time point at which kidney precursor cells, of both human and pig origin, differentiate into functional nephrons and not into other, non-renal professional cell types. Moreover, successful organogenesis is achieved when using the early kidney precursors, but not later-gestation kidneys. The formed, miniature kidneys are functional as evidenced by the dilute urine they produce. In addition, decreased immunogenicity of the transplants of early human and pig kidney precursors compared with adult kidney transplants is demonstrated in vivo. Our data pinpoint a window of human and pig kidney organogenesis that may be optimal for transplantation in humans.
AB - Kidney transplantation has been one of the major medical advances of the past 30 years. However, tissue availability remains a major obstacle. This can potentially be overcome by the use of undifferentiated or partially developed kidney precursor cells derived from early embryos and fetal tissue. Here, transplantation in mice reveals the earliest gestational time point at which kidney precursor cells, of both human and pig origin, differentiate into functional nephrons and not into other, non-renal professional cell types. Moreover, successful organogenesis is achieved when using the early kidney precursors, but not later-gestation kidneys. The formed, miniature kidneys are functional as evidenced by the dilute urine they produce. In addition, decreased immunogenicity of the transplants of early human and pig kidney precursors compared with adult kidney transplants is demonstrated in vivo. Our data pinpoint a window of human and pig kidney organogenesis that may be optimal for transplantation in humans.
UR - http://www.scopus.com/inward/record.url?scp=0037231480&partnerID=8YFLogxK
U2 - 10.1038/nm812
DO - 10.1038/nm812
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C2 - 12496960
AN - SCOPUS:0037231480
SN - 1078-8956
VL - 9
SP - 53
EP - 60
JO - Nature Medicine
JF - Nature Medicine
IS - 1
ER -
