Human-Based Immune Responsive In Vitro Infection Models for Validation of Novel TLR4 Antagonists Identified by Computational Discovery

Keyphrases

• Toll-like Receptor 4 (TLR4) 100%
• Human-based 100%
• Computational Discovery 100%
• In Vitro Infection Model 100%
• TLR4 Antagonist 100%
• Infectious Diseases 66%
• Fungal Infection 66%
• Anti-infective 66%
• Skin Infection Models 66%
• 3D Skin 66%
• Cell Wall Components 33%
• Inflammatory Diseases 33%
• CD14 33%
• Immune Response 33%
• Computational Methods 33%
• Innate Immune Response 33%
• Microbial Infection 33%
• Candida Albicans (C. albicans) 33%
• Increasing Complexity 33%
• Bacterial Infection 33%
• Host Immune Response 33%
• Toll-like 33%
• Lipopolysaccharide 33%
• Drug Development 33%
• Molecular Docking 33%
• Infection Model 33%
• Co-receptor 33%
• Cytokine Response 33%
• Chemokine Responses 33%
• Microbial Cell Walls 33%
• Pathogen Recognition 33%
• Pharmacophore Modeling 33%
• Immune-modulating Drugs 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Infection 100%
• Toll Like Receptor 4 100%
• Mycosis 40%
• Skin Infection 40%
• Anti-Inflammatory Drug 20%
• Cytokine 20%
• Drug Development 20%
• Receptor 20%
• Candida Albicans 20%
• Bacterial Infection 20%
• Toll Like Receptor 20%
• Infectious Agent 20%
• Chemokine 20%
• Inflammatory Disease 20%

Immunology and Microbiology

• TLR4 100%
• Immunity 100%
• CD14 16%
• Inflammatory Disorder 16%
• Cell Wall 16%
• Infectious Agent 16%
• Infectious Disease 16%
• Innate Immune System 16%
• Immune System 16%
• Toll-Like Receptor 16%
• Immune Response 16%
• Candida Albicans 16%
• Cytokine Response 16%
• Pharmacophore 16%
• Molecular Docking 16%
• Chemokine Response 16%