Human cytomegalovirus induces a distinct innate immune response in the maternal-fetal interface

Yiska Weisblum, Amos Panet, Zichria Zakay-Rones, Alon Vitenshtein, Ronit Haimov-Kochman, Debra Goldman-Wohl, Esther Oiknine-Djian, Rachel Yamin, Karen Meir, Hagai Amsalem, Tal Imbar, Ofer Mandelboim, Simcha Yagel, Dana G. Wolf*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The initial interplay between human cytomegalovirus (HCMV) and innate tissue response in the human maternal-fetal interface, though crucial for determining the outcome of congenital HCMV infection, has remained unknown. We studied the innate response to HCMV within the milieu of the human decidua, the maternal aspect of the maternal-fetal interface, maintained ex vivo as an integral tissue. HCMV infection triggered a rapid and robust decidual-tissue innate immune response predominated by interferon (IFN)γ and IP-10 induction, dysregulating the decidual cytokine/chemokine environment in a distinctive fashion. The decidual-tissue response was already elicited during viral-tissue contact, and was not affected by neutralizing HCMV antibodies. Of note, IFNγ induction, reflecting immune-cell activation, was distinctive to the maternal decidua, and was not observed in concomitantly-infected placental (fetal) villi. Our studies in a clinically-relevant surrogate human model, provide a novel insight into the first-line decidual tissue response which could affect the outcome of congenital infection.

Original languageAmerican English
Pages (from-to)289-296
Number of pages8
StatePublished - 1 Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.


  • Congenital viral infection
  • Decidua
  • Human cytomegalovirus
  • Innate immune response
  • Maternal-fetal interface
  • Placental infection


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