Human D3 dopamine receptor in the medulloblastoma TE671 cell line: cross-talk between D1 and D3 receptors

Berta Levavi-Sivan, Bae Hang Park, Sara Fuchs*, C. Simone Fishburn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

In search of a cell line in which the D3 dopamine receptor is expressed endogenously, we found that the neuron-derived human medulloblastoma cell line TE671 expresses the human D3 (hD3) and D1 (hD1) receptor, but neither the D2 or D4 receptors. Exposure of TE671 cells to the D3 agonist 7-OH-DPAT (DPAT), or to the D1 agonist SKF-38393 (SKF) increased the expression of hD3 or hD1 mRNA, respectively. Moreover, whereas DPAT had no effect on hD1 mRNA levels, stimulating the cells with SKF caused an increase in both hD1 and hD3 transcript levels. These results suggest (i) that following ligand stimulation, hD3 and hD1 receptors are upregulated to enhance their own receptor expression, and (ii) that upregulation of hD1 receptor transcripts leads to a stimulation of the hD3 dopamine receptor transcripts. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageAmerican English
Pages (from-to)138-142
Number of pages5
JournalFEBS Letters
Volume439
Issue number1-2
DOIs
StatePublished - 13 Nov 1998
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from the Irwin Green Research Fund in Neurosciences, the United States-Israel Binational Science Foundation (BSF), and the Leo and Julia Forchheimer Center for Molecular Genetics at the Weizmann Institute of Science.

Keywords

  • D
  • D
  • Dopamine receptor
  • Human
  • TE671

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