TY - JOUR
T1 - Human embryonic stem cells as a cellular model for human disorders
AU - Ben-Nun, Inbar Friedrich
AU - Benvenisty, Nissim
PY - 2006/6/27
Y1 - 2006/6/27
N2 - Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.
AB - Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.
KW - Gene trap
KW - Genetic diseases
KW - Genetic manipulation
KW - Human disorders
KW - Human embryonic stem cells
KW - Nuclear transfer
KW - Preimplantation genetic diagnosis
UR - http://www.scopus.com/inward/record.url?scp=33745222812&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2006.03.034
DO - 10.1016/j.mce.2006.03.034
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 16690205
AN - SCOPUS:33745222812
SN - 0303-7207
VL - 252
SP - 154
EP - 159
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -