Human embryonic stem cells as a cellular model for human disorders

Inbar Friedrich Ben-Nun; Nissim Benvenisty

doi:10.1016/j.mce.2006.03.034

Human embryonic stem cells as a cellular model for human disorders

Inbar Friedrich Ben-Nun, Nissim Benvenisty^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.

Original language	American English
Pages (from-to)	154-159
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	252
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2006.03.034
State	Published - 27 Jun 2006

Keywords

Gene trap
Genetic diseases
Genetic manipulation
Human disorders
Human embryonic stem cells
Nuclear transfer
Preimplantation genetic diagnosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mce.2006.03.034

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title = "Human embryonic stem cells as a cellular model for human disorders",

abstract = "Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.",

keywords = "Gene trap, Genetic diseases, Genetic manipulation, Human disorders, Human embryonic stem cells, Nuclear transfer, Preimplantation genetic diagnosis",

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AU - Benvenisty, Nissim

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N2 - Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.

AB - Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.

KW - Gene trap

KW - Genetic diseases

KW - Genetic manipulation

KW - Human disorders

KW - Human embryonic stem cells

KW - Nuclear transfer

KW - Preimplantation genetic diagnosis

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JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

IS - 1-2

ER -

Human embryonic stem cells as a cellular model for human disorders

Abstract

Keywords

UN SDGs

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