Human embryonic stem cells as a cellular model for human disorders

Inbar Friedrich Ben-Nun, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Human embryonic stem cells (HESCs) are pluripotent cell lines derived from the inner cell mass (ICM) of embryos at the blastocyst stage. These cells possess self renewal capacity and differentiation potential to all three embryonic germ layers. These unique characters made HESCs an attractive research tool for studying early human developmental processes as well as a potential therapeutic tool for various human diseases. Here, we focus on HESCs as a cellular model for human disorders. The advantages of such models as well as the various methodologies to achieve HESCs carrying a genetic defect will be discussed.

Original languageAmerican English
Pages (from-to)154-159
Number of pages6
JournalMolecular and Cellular Endocrinology
Issue number1-2
StatePublished - 27 Jun 2006


  • Gene trap
  • Genetic diseases
  • Genetic manipulation
  • Human disorders
  • Human embryonic stem cells
  • Nuclear transfer
  • Preimplantation genetic diagnosis


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