Human embryonic stem cells as a model for early human development

Tamar Dvash, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Although, the study of human development-from fertilized egg to mature embryo-is extremely important, the early differentiation of human tissues remains an enigma. Moreover, the relatively high percentage of unexplained pregnancy loss-a major concern of human embryologists and gynaecologists-emphasizes the need for an appropriate model for studying early human development. The availability of human pluripotent stem cells might allow us to study previously inaccessible basic processes that occur during human embryogenesis, such as gastrulation and organogenesis.

Original languageAmerican English
Pages (from-to)929-940
Number of pages12
JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
Issue number6
StatePublished - Dec 2004


  • Differentiation
  • Embryogenesis
  • Human development
  • Organogenesis
  • Pluripotency
  • Stem cells


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