Human protease-activated receptor 1 expression in malignant epithelia: A role in invasiveness

Yong Jun Yin; Zaidoun Salah; Sorina Grisaru-Granovsky; Irit Cohen; Sharona Cohen Even-Ram; Myriam Maoz; Beatrice Uziely; Tamar Peretz; Rachel Bar-Shavit

doi:10.1161/01.ATV.0000066878.27340.22

Human protease-activated receptor 1 expression in malignant epithelia: A role in invasiveness

Yong Jun Yin
, Zaidoun Salah
, Sorina Grisaru-Granovsky
, Irit Cohen
, Sharona Cohen Even-Ram
, Myriam Maoz
, Beatrice Uziely
, Tamar Peretz
, Rachel Bar-Shavit^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.

Original language	English
Pages (from-to)	940-944
Number of pages	5
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1161/01.ATV.0000066878.27340.22
State	Published - 1 Jun 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis
Epithelia
Invasion
Metastasis
PAR1

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10.1161/01.ATV.0000066878.27340.22

Cite this

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title = "Human protease-activated receptor 1 expression in malignant epithelia: A role in invasiveness",

abstract = "While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.",

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T2 - A role in invasiveness

AU - Yin, Yong Jun

AU - Salah, Zaidoun

AU - Grisaru-Granovsky, Sorina

AU - Cohen, Irit

AU - Even-Ram, Sharona Cohen

AU - Maoz, Myriam

AU - Uziely, Beatrice

AU - Peretz, Tamar

AU - Bar-Shavit, Rachel

PY - 2003/6/1

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N2 - While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.

AB - While protease-activated receptors (PARs) play a traditional role in vascular biology, they emerge with surprisingly new assignments in tumor biology. PAR1 expression correlates with the invasion properties of breast carcinoma, whereas human PAR1 antisense reduces their ability to migrate through Matrigel. Part of the molecular mechanism of PAR1 invasion involves the formation of focal contact complexes on PAR1 activation. PAR1 induces angiogenesis in animal models in vivo and exhibits an oncogenic phenotype of enhanced ductal complexity when overexpressed in mouse mammary glands.

KW - Angiogenesis

KW - Epithelia

KW - Invasion

KW - Metastasis

KW - PAR1

UR - https://www.scopus.com/pages/publications/0037783286

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AN - SCOPUS:0037783286

SN - 1079-5642

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SP - 940

EP - 944

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 6

ER -

Human protease-activated receptor 1 expression in malignant epithelia: A role in invasiveness

Abstract

UN SDGs

Keywords

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