Human ribonuclease P: Subunits, function, and intranuclear localization

Nayef Jarrous*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations

Abstract

Catalytic complexes of nuclear ribonuclease P (RNase P) ribonucleoproteins are composed of several protein subunits that appear to have specific roles in enzyme function in tRNA processing. This review describes recent progress made in the characterization of human RNase P, its relationship with the ribosomal RNA processing ribonucleoprotein RNase MRP, and the unexpected evolutionary conservation of its subunits. A new model for the biosynthesis of human RNase P is presented, in which this process is dynamic, transcription-dependent, and implicates functionally distinct nuclear compartments in tRNA biogenesis.

Original languageAmerican English
Pages (from-to)1-7
Number of pages7
JournalRNA
Volume8
Issue number1
DOIs
StatePublished - 2002

Keywords

  • Cajal bodies
  • Catalytic ribonucleoprotein
  • Nucleolus
  • RNase MRP
  • RNase P
  • tRNA

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