Human RNase P: A tRNA-processing enzyme and transcription factor

Nayef Jarrous*, Robert Reiner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Ribonuclease P (RNase P) has been hitherto well known as a catalytic ribonucleoprotein that processes the 5′ leader sequence of precursor tRNA. Recent studies, however, reveal a new role for nuclear forms of RNase P in the transcription of tRNA genes by RNA polymerase (pol) III, thus linking transcription with processing in the regulation of tRNA gene expression. However, RNase P is also essential for the transcription of other small noncoding RNA genes, whose precursor transcripts are not recognized as substrates for this holoenzyme. Accordingly, RNase P can act solely as a transcription factor for pol III, a role that seems to be conserved in eukarya.

Original languageAmerican English
Pages (from-to)3519-3524
Number of pages6
JournalNucleic Acids Research
Issue number11
StatePublished - Jun 2007

Bibliographical note

Funding Information:
We thank Venkat Gopalan (The Ohio State University, Columbus, OH) for his valuable comments on the manuscript. This research is supported by the United States–Israel Binational Science Foundation (grant no. 2005/009) and the Israel Science Foundation (grant no. 673/06) to N.J. Funding to pay the Open Access publication charge was provided by The Israel Science Foundation.


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