Hydration of AMP and ATP molecules in aqueous solution and solid films

Dzhigangir Faizullin; Nataliya Zakharchenko; Yuriy Zuev; Alexander Puzenko; Evgeniya Levy; Yuri Feldman

doi:10.3390/ijms141122876

Hydration of AMP and ATP molecules in aqueous solution and solid films

Dzhigangir Faizullin^*, Nataliya Zakharchenko, Yuriy Zuev, Alexander Puzenko, Evgeniya Levy, Yuri Feldman

^*Corresponding author for this work

Department of Applied Physics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Water enables life and plays a critical role in biology. Considered as a versatile and adaptive component of the cell, water engages a wide range of biomolecular interactions. An organism can exist and function only if its self-assembled molecular structures are hydrated. It was shown recently that switching of AMP/ATP binding to the insulin-independent glucose transporter Human Erythrocyte Glucose Transport Protein (GLUT1) may greatly influence the ratio of bulk and bound water during regulation of glucose uptake by red blood cells. In this paper, we present the results on the hydration properties of AMP/ATP obtained by means of dielectric spectroscopy in aqueous solution and for fully ionized forms in solid amorphous films with the help of gravimetric studies.

Original language	American English
Pages (from-to)	22876-22890
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	14
Issue number	11
DOIs	https://doi.org/10.3390/ijms141122876
State	Published - 20 Nov 2013

Keywords

Bound water
Dielectric spectroscopy
Nucleotides
Quartz crystal microbalance

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10.3390/ijms141122876

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AU - Faizullin, Dzhigangir

AU - Zakharchenko, Nataliya

AU - Zuev, Yuriy

AU - Puzenko, Alexander

AU - Levy, Evgeniya

AU - Feldman, Yuri

PY - 2013/11/20

Y1 - 2013/11/20

N2 - Water enables life and plays a critical role in biology. Considered as a versatile and adaptive component of the cell, water engages a wide range of biomolecular interactions. An organism can exist and function only if its self-assembled molecular structures are hydrated. It was shown recently that switching of AMP/ATP binding to the insulin-independent glucose transporter Human Erythrocyte Glucose Transport Protein (GLUT1) may greatly influence the ratio of bulk and bound water during regulation of glucose uptake by red blood cells. In this paper, we present the results on the hydration properties of AMP/ATP obtained by means of dielectric spectroscopy in aqueous solution and for fully ionized forms in solid amorphous films with the help of gravimetric studies.

AB - Water enables life and plays a critical role in biology. Considered as a versatile and adaptive component of the cell, water engages a wide range of biomolecular interactions. An organism can exist and function only if its self-assembled molecular structures are hydrated. It was shown recently that switching of AMP/ATP binding to the insulin-independent glucose transporter Human Erythrocyte Glucose Transport Protein (GLUT1) may greatly influence the ratio of bulk and bound water during regulation of glucose uptake by red blood cells. In this paper, we present the results on the hydration properties of AMP/ATP obtained by means of dielectric spectroscopy in aqueous solution and for fully ionized forms in solid amorphous films with the help of gravimetric studies.

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KW - Nucleotides

KW - Quartz crystal microbalance

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Hydration of AMP and ATP molecules in aqueous solution and solid films

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