Hydration of AMP and ATP molecules in aqueous solution and solid films

Dzhigangir Faizullin*, Nataliya Zakharchenko, Yuriy Zuev, Alexander Puzenko, Evgeniya Levy, Yuri Feldman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Water enables life and plays a critical role in biology. Considered as a versatile and adaptive component of the cell, water engages a wide range of biomolecular interactions. An organism can exist and function only if its self-assembled molecular structures are hydrated. It was shown recently that switching of AMP/ATP binding to the insulin-independent glucose transporter Human Erythrocyte Glucose Transport Protein (GLUT1) may greatly influence the ratio of bulk and bound water during regulation of glucose uptake by red blood cells. In this paper, we present the results on the hydration properties of AMP/ATP obtained by means of dielectric spectroscopy in aqueous solution and for fully ionized forms in solid amorphous films with the help of gravimetric studies.

Original languageAmerican English
Pages (from-to)22876-22890
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume14
Issue number11
DOIs
StatePublished - 20 Nov 2013

Keywords

  • Bound water
  • Dielectric spectroscopy
  • Nucleotides
  • Quartz crystal microbalance

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