Hydrogel-integrated 3D-printed poly(lactic acid) scaffolds for bone tissue engineering

Mitun Das, Orna Sharabani-Yosef, Noam Eliaz*, Daniel Mandler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Abstract: There is currently a high demand for synthetic biodegradable scaffolds with enhanced osteogenic and angiogenic performance for the regeneration of large-size bone defects. Here, hybrid scaffolds were prepared by integrating either alginate or alginate–bioglass composite hydrogels with a 3D-printed poly(lactic acid) (PLA) porous structure. The as-deposited PLA scaffolds were surface treated with polyacrylic acid (PAA), which significantly enhanced the PLA scaffold’s wettability. The surface-modified PLA scaffolds integrated well with hydrogels and provided shape and mechanical rigidity to the hydrogel. In phosphate-buffered saline, the lowest weight loss during 21-days immersion was measured for the PLA scaffold, while alginate–bioglass scaffolds lost ~ 1.9% weight during the first 7 days of immersion. In vitro cytocompatibility tests indicated good cell viability and cell proliferation on the scaffolds. The bioglass-containing hybrid scaffold promoted osteogenic differentiation and calcium mineralization. The excellent biocompatibility, good mechanical stability of the hydrogel, and shape retention of the novel hybrid scaffolds with cell-laden alginate could make them attractive for large bone regeneration. Graphic abstract: [Figure not available: see fulltext.]

Original languageAmerican English
Pages (from-to)3833-3842
Number of pages10
JournalJournal of Materials Research
Issue number19
StatePublished - 14 Oct 2021

Bibliographical note

Funding Information:
We are grateful to the Israel Ministry of Science and Technology for funding this research via grant # 3-15634. MD is thankful also to the TATA Education and Development Trust, India, for financial support.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to The Materials Research Society.


  • Additive manufacturing
  • Alginate–bioglass hydrogel
  • Biomedical
  • Bone
  • In vitro cell culture
  • Poly(lactic acid) (PLA)


Dive into the research topics of 'Hydrogel-integrated 3D-printed poly(lactic acid) scaffolds for bone tissue engineering'. Together they form a unique fingerprint.

Cite this